{"id":97064,"date":"2009-06-11T00:00:00","date_gmt":"2009-06-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monocytes-mediated-endothelial-function-in-vascular-pathology\/"},"modified":"2009-06-11T00:00:00","modified_gmt":"2009-06-11T00:00:00","slug":"monocytes-mediated-endothelial-function-in-vascular-pathology","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/monocytes-mediated-endothelial-function-in-vascular-pathology\/","title":{"rendered":"Monocytes-mediated endothelial function in vascular pathology"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Benarroch Hernansaez <\/strong><\/h2>\n<p>La tesis examina distintos aspectos del papel que tienen los monocitos en preservar la homeostasis endotelial bajo condiciones de fisiol\u00f3gicas y de estr\u00e9s. Se ha estudiado la interacci\u00f3n de los monocitos primarios con c\u00e9lulas endoteliales humanas en la regulaci\u00f3n de la proliferaci\u00f3n endotelial, su migraci\u00f3n, la supervivencia y la formaci\u00f3n de estructuras tubulares formadas por endotelio.  los principales hallazgos de este estudio sugieren que la interacci\u00f3n temprana de monocitos primarios inactivados con c\u00e9lulas endoteliales es cr\u00edtica para la regulaci\u00f3n de la proliferaci\u00f3n de las c\u00e9lulas endoteliales y de su supervivencia. Esta compleja interacci\u00f3n est\u00e1 parcialmente mediada por el contacto directo entre ambos tipos celulares y la activaci\u00f3n del receptor met y de erk1\/2. Adem\u00e1s queda demostrado que este efecto no es debido a la activaci\u00f3n de flk-1 ni de la presencia de los factores de crecimiento vegf, fgf o pdgf. adem\u00e1s los monocitos pueden inducir la reparaci\u00f3n de heridas endoteliales en un modelo in-vitro as\u00ed como estimular la formaci\u00f3n de estructuraqs de tipo capilar en c\u00e9lulas endoteliales. finalmente, cabe destacar que los hallazgos presentados ilustran un nuevo mecanismo de interacci\u00f3n entre los monocitos circulantes con las c\u00e9lulas endoteliales mediante el cual los primeros pueden restaurar\/preservar la homeostasis vascular mediante la estimulaci\u00f3n de la proliferaci\u00f3n, migraci\u00f3n, reparaci\u00f3n y supervivencia endotelial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monocytes-mediated endothelial function in vascular pathology<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monocytes-mediated endothelial function in vascular pathology <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Benarroch Hernansaez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Pedro Casaroli Marano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: oriol Bachs valldeneu <\/li>\n<li>Mar\u00eda Buxad\u00e9 fortuny (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Benarroch Hernansaez La tesis examina distintos aspectos del papel que tienen los monocitos en preservar la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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