{"id":97222,"date":"2018-03-11T10:17:41","date_gmt":"2018-03-11T10:17:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-pruebas-diagnosticas-en-el-estudio-de-la-alergia-inmediata-selectiva-a-amoxicilina\/"},"modified":"2018-03-11T10:17:41","modified_gmt":"2018-03-11T10:17:41","slug":"estudio-de-las-pruebas-diagnosticas-en-el-estudio-de-la-alergia-inmediata-selectiva-a-amoxicilina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alergias\/estudio-de-las-pruebas-diagnosticas-en-el-estudio-de-la-alergia-inmediata-selectiva-a-amoxicilina\/","title":{"rendered":"Estudio de las pruebas diagn\u00f3sticas en el estudio de la alergia inmediata selectiva a amoxicilina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Ruano P\u00e9rez <\/strong><\/h2>\n<p>Los antibi\u00f3ticos \u00edY-lact\u00e1micos han representado y representan una de las opciones terape\u00faticas m\u00e1s importantes en la medicina actual. Pr\u00e1cticamente desde que comenzaron a utilizarse se han descrito reacciones al\u00e9rgicas a estos f\u00e1rmacos, siendo en la actualidad la causa m\u00e1s frecuente de reacci\u00f3n al\u00e9rgica a f\u00e1rmacos mediada por un mecanismo inmunol\u00f3gico. Con este trabajo, recogemos la experiencia cl\u00ednica, de tres a\u00f1os y medio de estudio, en un grupo de pacientes al\u00e9rgicos a antibi\u00f3ticos de la familia de los \u00edY-lact\u00e1micos, concretamente con alergia selectiva a amoxicilina. la hip\u00f3tesis de trabajo es determinar si con las pruebas diagn\u00f3sticas utilizadas en la pr\u00e1ctica cl\u00ednica diaria, es posible establecer en los pacientes con reacciones de hipersensibilidad a antibi\u00f3ticos \u00edY-lact\u00e1micos el diagn\u00f3stico de la alergia inmediata selectiva a amoxicilina. Se incluyeron en el estudio 1436 pacientes con historia compatible de haber presentado una reacci\u00f3n al\u00e9rgica inmediata a un f\u00e1rmaco \u00edY-lact\u00e1mico. A todos ellos se les realiz\u00f3 el mismo protocolo diagn\u00f3stico adaptado del utilizado por el grupo europeo de alergia a f\u00e1rmacos (enda: european network for drug allergy) que incluye la realizaci\u00f3n de la historia cl\u00ednica, realizaci\u00f3n de pruebas cut\u00e1neas y prurebas de laborartorio y finalmente cuando se considera necesario de la administraci\u00f3n controlada del f\u00e1rmaco.  Tras la realizaci\u00f3n del protocolo fueron 186 (12.95%) los pacientes que fueron diagnosticados de alergia a \u00edY-lact\u00e1micos y de \u00e9stos 95 (51%) presentaban una alergia inmediata selectiva a amoxicilina. Se ha observado que las pruebas cut\u00e1neas con este f\u00e1rmaco fueron positivas en un porcentaje elevado de pacientes,cercano al 27%, no siendo necesaria la realizaci\u00f3n de la administraci\u00f3n controlada de amoxicilina para alcanzar el diagn\u00f3stico, evitando as\u00ed un mayor riesgo al paciente. La determinaci\u00f3n de anticuerpos ige espec\u00edficos mediante el m\u00e9todo cap no ha resultado determinante, indicando que esta prueba no est\u00e1 claramente validada en el estudio de la alergia inmediata selectiva a amoxicilina. En todos los casos se comprob\u00f3 la tolerancia a penicilina y cefuroxima. Se comprob\u00f3 que la el protocolo utilizado en fases sucesivas era seguro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las pruebas diagn\u00f3sticas en el estudio de la alergia inmediata selectiva a amoxicilina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las pruebas diagn\u00f3sticas en el estudio de la alergia inmediata selectiva a amoxicilina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Ruano P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>F\u00e9lix Lorente Toledano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Prieto veiga <\/li>\n<li>Francisco Javier Fern\u00e1ndez s\u00e1nchez (vocal)<\/li>\n<li>Miguel Blanca g\u00f3mez (vocal)<\/li>\n<li>Jos\u00e9 augusto Garc\u00eda-ag\u00fandez p\u00e9rez-coca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Ruano P\u00e9rez Los antibi\u00f3ticos \u00edY-lact\u00e1micos han representado y representan una de las opciones terape\u00faticas m\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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