{"id":97279,"date":"2018-03-11T10:17:46","date_gmt":"2018-03-11T10:17:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-expresion-de-genes-reguladores-de-la-homeostasis-osea-por-bmp-2\/"},"modified":"2018-03-11T10:17:46","modified_gmt":"2018-03-11T10:17:46","slug":"modulacion-de-la-expresion-de-genes-reguladores-de-la-homeostasis-osea-por-bmp-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/modulacion-de-la-expresion-de-genes-reguladores-de-la-homeostasis-osea-por-bmp-2\/","title":{"rendered":"Modulaci\u00f3n de la expresi\u00f3n de genes reguladores de la homeostasis \u00f3sea por bmp-2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Ram\u00f3n Garc\u00eda Susperregui <\/strong><\/h2>\n<p>Los resultados de estas tesis demuestran la regulaci\u00f3n de pthrp y su receptor por bmp-2 durante la diferenciaci\u00f3n osteobl\u00e1stoca de c\u00e9lulas c2c12. En ambos casos la regulaci\u00f3n ocurre a nivel transcripcional y concretamente pth1r es regulado tanto por la v\u00eda can\u00f3nica como por la v\u00eda alternativa de transcducci\u00f3n de la se\u00f1al de bmp-2. En paralelo pero de manera independiente a la modulaci\u00f3n del eje pthrp\/pth1r bmp-2 regula la expresi\u00f3n de citoquinas osteoclastog\u00e9nicas como son opg (osteoprotegerina), rankl (receptor activator of nuclear factor-\u00c2\u00bfb ligand) y m-csf (macrophage-colony stimulating factor).   adicionalmente el trabajo identifica a msk1 (mitogen and stress activated protein kinase) y sus substratos de fosforilaci\u00f3n creb (camp response element-binding protein) y p65 como posibles efectores a nivel del adn de la transducci\u00f3n de la se\u00f1al de bmp-2 por la v\u00eda alternativa de la mapk (mitogen-activated protein kinases) p38. Con el uso de inhibidores espec\u00edficos de dicha ruta y construcciones de los promotores g\u00e9nicos se demuestra que la expresi\u00f3n de cox2 y junb est\u00e1 modulada por dicha ruta, aunque la inducci\u00f3n de la expresi\u00f3n de il6 parece ser independiente de la misma a pesar de haber involucrado a p65.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la expresi\u00f3n de genes reguladores de la homeostasis \u00f3sea por bmp-2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la expresi\u00f3n de genes reguladores de la homeostasis \u00f3sea por bmp-2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Ram\u00f3n Garc\u00eda Susperregui <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Ventura Pujol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Bartrons bach <\/li>\n<li>eva Gonz\u00e1lez su\u00e1rez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Ram\u00f3n Garc\u00eda Susperregui Los resultados de estas tesis demuestran la regulaci\u00f3n de pthrp y su receptor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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