{"id":97311,"date":"2018-03-11T10:17:50","date_gmt":"2018-03-11T10:17:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetic-and-environmental-factors-in-asthma-a-population-based-european-study\/"},"modified":"2018-03-11T10:17:50","modified_gmt":"2018-03-11T10:17:50","slug":"genetic-and-environmental-factors-in-asthma-a-population-based-european-study","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pompeu-fabra\/genetic-and-environmental-factors-in-asthma-a-population-based-european-study\/","title":{"rendered":"Genetic and environmental factors in asthma: a population based european study"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francesc Castro Giner <\/strong><\/h2>\n<p>Asma es una enfermedad de etiolog\u00eda compleja, formada por factores gen\u00e9ticos y ambientales, donde la interrelaci\u00f3n de ambos factores mediante interacciones gen-ambiente juega un papel clave. El objetivo de esta tesis ha sido profundizar en el conocimiento del papel de los polimorfismos gen\u00e9ticos, y su interacci\u00f3n con factores ambientales, en la ocurrencia de asma, atopia y hiperreactividad bronquial. Este objetivo ha sido desarrollado a trav\u00e9s de la replicaci\u00f3n de variantes gen\u00e9ticas previamente identificadas, la evaluaci\u00f3n de interacciones gen-ambiente y la identificaci\u00f3n de nuevos genes de susceptibilidad mediante un dise\u00f1o basado en el genotipage de variantes gen\u00e9ticas a lo largo del genoma en pools de adn. La tesis ha estado mayoritariamente llevada a cabo dentro del estudio european community respiratory health survey (ecrhs) que agrupa mas de 5.000 individuos seguidos durante 9 a\u00f1os, para los cuales se dispone de un cuestionario completo sobre s\u00edntomas respiratorios, evaluaciones cl\u00ednicas, informaci\u00f3n sobre exposiciones ambientales y muestras de adn. Se ha replicado la asociaci\u00f3n del polimorfismo tnfa-308ga con asma y se ha establecido su efecto sobre la enfermedad mediante un meta-an\u00e1lisis completo. Tambi\u00e9n se han replicado evidencias previas sobre el efecto de los genes identificados por clonaci\u00f3n posicional npsr1 y adam33. Tambi\u00e9n el an\u00e1lisis seg\u00fan edad de inicio sugiere un papel mas agudo de npsr1 sobre asma originada en edades precoces, particularmente a trav\u00e9s del efecto de este gen en asma combinada con atopia, fenotipo de asma com\u00fan en la etapa pre-puberal. Una revisi\u00f3n de los estudios que eval\u00faan interacciones entre exposiciones ambientales, polimorfismos gen\u00e9ticos y asma ha mostrado que la investigaci\u00f3n en las bases gen\u00e9ticas y interacciones en asma continua incompleta, con pocos genes y pocas interacciones establecidas. El an\u00e1lisis de interacciones muestra la importancia de integrar investigaci\u00f3n gen\u00e9tica con datos ambientales y estilos de vida. Esta tesis tambi\u00e9n describe las interacciones de nqo1 y contaminaci\u00f3n relacionada con el tr\u00e1fico de veh\u00edculos, y el efecto conjunto de tnfa y obesidad en asma de origen no atopico. El an\u00e1lisis de pools de adn ha permitido asociar la regi\u00f3n donde se sit\u00faa el gen sgk493 con atopia. Esta tesis contribuye al conocimiento de la etiolog\u00eda de asma con la identificaci\u00f3n y replicaci\u00f3n de asociaciones gen\u00e9ticas y interacciones gen-ambiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genetic and environmental factors in asthma: a population based european study<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genetic and environmental factors in asthma: a population based european study <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francesc Castro Giner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manolis Kogevinas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ferran Morell brotad <\/li>\n<li>m\u00f3nica Gratac\u00ed\u00b2s mayora (vocal)<\/li>\n<li>v\u00edctor ra\u00fal Moreno aguado (vocal)<\/li>\n<li>valerie Siroux (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francesc Castro Giner Asma es una enfermedad de etiolog\u00eda compleja, formada por factores gen\u00e9ticos y ambientales, donde [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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