{"id":97397,"date":"2018-03-11T10:17:55","date_gmt":"2018-03-11T10:17:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/linfoma-esplenico-de-la-zona-marginal-caracterizacion-molecular\/"},"modified":"2018-03-11T10:17:55","modified_gmt":"2018-03-11T10:17:55","slug":"linfoma-esplenico-de-la-zona-marginal-caracterizacion-molecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/linfoma-esplenico-de-la-zona-marginal-caracterizacion-molecular\/","title":{"rendered":"Linfoma espl\u00e9nico de la zona marginal. caracterizaci\u00f3n molecular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Mar\u00eda Ruiz Ballesteros <\/strong><\/h2>\n<p>Null en esta tesis se profundiza en el conocimiento de las bases moleculares de la patog\u00e9nesis del linfoma espl\u00e9nico de la zona marginal (lezm), una entidad recientemente descrita cuya investigaci\u00f3n deber\u00eda permitir identificar y proponer nuevos marcadore s diagn\u00f3sticos, pron\u00f3sticos y dianas terap\u00e9uticas que mejoren la estratificaci\u00f3n de pacientes sobre la base de un diagn\u00f3stico preciso y una terapia racional.  el estudio consiste en el an\u00e1lisis de la expresi\u00f3n g\u00e9nica en lezm mediante micro-matrices d e adn codificante, de su expresi\u00f3n prote\u00ednica mediante matrices de tejido y de la frecuencia de mutaciones en los genes que codifican la regi\u00f3n variable de las cadenas pesadas de las inmunoglobulinas (igvh). Los resultados fueron relacionados con par \u00e1metros cl\u00ednicos. Adem\u00e1s, se analiz\u00f3 la expresi\u00f3n de determinados micrornas localizados en el brazo largo del cromosoma 7 (7q) (regi\u00f3n frecuentemente perdida en los lezm).  as\u00ed, este trabajo ha permitido el reconocimiento del lezm como entidad molecu lar \u00fanica y distinta de otros linfomas b de c\u00e9lula peque\u00f1a (lbcp).  se ha identificado una firma molecular propia de este tipo de linfoma, revel\u00e1ndose lo que parecen ser las rutas claves en su oncog\u00e9nesis como la se\u00f1alizaci\u00f3n a partir de receptores: tnf y bcr y la activaci\u00f3n a trav\u00e9s de nf-kb y pi3k\/akt, posiblemente dependientes del oncogen tcl1. Se han propuesto nuevos marcadores de inter\u00e9s diagn\u00f3stico como il1f, setx y cd40 diferencialmente expresados en lezm frente a otros lbcp. Otros marcad ores con potencial valor pron\u00f3stico como el estado mutacional de los genes igvh, la expresi\u00f3n de las prote\u00ednas cd38, syk y ki67 y la expresi\u00f3n de un grupo de genes de la ruta nf-kb. Tambi\u00e9n se han identificado marcadores con potencial aplicaci\u00f3n tera p\u00e9utica como las rutas pi3k\/akt, nf-kb y los genes syk, prkca o cd52. por \u00faltimo, la regi\u00f3n cromos\u00f3mica 7q31-32,  frecuentemente perdida en los lezm, alberga genes reprimidos (cav1, cav2 y gng11), as\u00ed como mirnas perdidos (hsa-mir-29b-1, hsa-mir-29a) , reguladores del oncogen tcl1, cuya p\u00e9rdida se propone como mecanismo esencial a explorar en la oncog\u00e9nesis de estos tumores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Linfoma espl\u00e9nico de la zona marginal. caracterizaci\u00f3n molecular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Linfoma espl\u00e9nico de la zona marginal. caracterizaci\u00f3n molecular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Mar\u00eda Ruiz Ballesteros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Piris Pinilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Guzm\u00e1n pastor <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Mar\u00eda Ruiz Ballesteros Null en esta tesis se profundiza en el conocimiento de las bases moleculares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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