{"id":97502,"date":"2018-03-11T10:18:03","date_gmt":"2018-03-11T10:18:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-translacional-de-los-efectos-del-disruptor-endocrino-di2etilhexil-ftalato-dehp-sobre-la-funcion-reproductiva-femenina-en-un-modelo-animal-ovino\/"},"modified":"2018-03-11T10:18:03","modified_gmt":"2018-03-11T10:18:03","slug":"estudio-translacional-de-los-efectos-del-disruptor-endocrino-di2etilhexil-ftalato-dehp-sobre-la-funcion-reproductiva-femenina-en-un-modelo-animal-ovino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-translacional-de-los-efectos-del-disruptor-endocrino-di2etilhexil-ftalato-dehp-sobre-la-funcion-reproductiva-femenina-en-un-modelo-animal-ovino\/","title":{"rendered":"Estudio translacional de los efectos del disruptor endocrino di(2etilhexil) ftalato (dehp) sobre la funci\u00f3n reproductiva femenina en un modelo animal ovino."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M Angeles Herreros Guerra <\/strong><\/h2>\n<p>Esta tesis doctoral aborda el dise\u00f1o y utilizaci\u00f3n de un modelo ovino para la valoraci\u00f3n de los efectos de la exposici\u00f3n a di(2-etilhexil) ftalato (dehp) sobre la funci\u00f3n ov\u00e1rica e hipofisaria, debido a las crecientes evidencias del efecto como disru ptor endocrino que presenta este compuesto. en el dise\u00f1o del modelo, se valoraron los niveles plasm\u00e1ticos de dehp en hembras no expuestas y el comportamiento cin\u00e9tico tras la exposici\u00f3n a diferentes dosis y v\u00edas de administraci\u00f3n de dehp. Un 38  de l as ovejas observadas presentaban evidencias de dehp; este porcentaje se incrementaba con la edad, posiblemente por un mayor periodo de exposici\u00f3n, y durante la gestaci\u00f3n, probablemente  debido a la movilizaci\u00f3n de las reservas corporales. El estudio cin\u00e9tico posterior mostr\u00f3 que la administraci\u00f3n de dosis m\u00faltiples de 25 y 50 mg\/kg de dehp, tres veces por semana, es adecuado modelo para valorar la toxicolog\u00eda reproductiva del dehp.  en el estudio de los efectos del dehp sobre la actividad reprod uctiva, se observ\u00f3 que la administraci\u00f3n de las dosis citadas durante dos meses se relacionaba con alteraciones en la actividad c\u00edclica ovulatoria, caracterizadas por la presencia de ciclos sexuales de corta duraci\u00f3n debido a cuerpos l\u00fateos de peque\u00f1 o di\u00e1metro y corta vida media. Sin embargo, las concentraciones plasm\u00e1ticas de progesterona eran significativamente mayores que en las ovejas control; este hallazgo, incompatible con las caracter\u00edsticas morfol\u00f3gicas de los cuerpos l\u00fateos, podr\u00eda ser consecuencia de alteraciones metab\u00f3licas. En un cuarto experimento se determin\u00f3 que estas alteraciones en la duraci\u00f3n y el tama\u00f1o de los cuerpos l\u00fateos podr\u00edan relacionarse con alteraciones en la secreci\u00f3n de lh, principal hormona luteotropa. Por otr o lado, se observaron lesiones hep\u00e1ticas que podr\u00edan causar disfunci\u00f3n hep\u00e1tica y alteraciones en el metabolismo de los esteroides; lo que explicar\u00eda los altos niveles de progesterona.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio translacional de los efectos del disruptor endocrino di(2etilhexil) ftalato (dehp) sobre la funci\u00f3n reproductiva femenina en un modelo animal ovino.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio translacional de los efectos del disruptor endocrino di(2etilhexil) ftalato (dehp) sobre la funci\u00f3n reproductiva femenina en un modelo animal ovino. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M Angeles Herreros Guerra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Gonzalez De Bulnes Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Luis Lorenzo gonzalez <\/li>\n<li>teresa de Jes\u00fas Roy p\u00e9rez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Navas ant\u00f3n (vocal)<\/li>\n<li>Fernando Forcada miranda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M Angeles Herreros Guerra Esta tesis doctoral aborda el dise\u00f1o y utilizaci\u00f3n de un modelo ovino para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[143369,29088,137415,199755,148749,136307],"class_list":["post-97502","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-gonzalez-de-bulnes-lopez","tag-fernando-forcada-miranda","tag-jose-maria-navas-anton","tag-m-angeles-herreros-guerra","tag-pedro-luis-lorenzo-gonzalez","tag-teresa-de-jesus-roy-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/97502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=97502"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/97502\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=97502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=97502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=97502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}