{"id":97518,"date":"2018-03-11T10:18:03","date_gmt":"2018-03-11T10:18:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/importancia-del-incremento-de-la-apoptosis-e-inhibicion-de-la-proliferacion-de-la-celula-beta-en-la-patogenia-de-la-diabetes-mellitus-autoinmune\/"},"modified":"2018-03-11T10:18:03","modified_gmt":"2018-03-11T10:18:03","slug":"importancia-del-incremento-de-la-apoptosis-e-inhibicion-de-la-proliferacion-de-la-celula-beta-en-la-patogenia-de-la-diabetes-mellitus-autoinmune","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/importancia-del-incremento-de-la-apoptosis-e-inhibicion-de-la-proliferacion-de-la-celula-beta-en-la-patogenia-de-la-diabetes-mellitus-autoinmune\/","title":{"rendered":"Importancia del incremento de la apoptosis e inhibici\u00f3n de la proliferaci\u00f3n de la c\u00e9lula beta en la patogenia de la diabetes mellitus autoinmune"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo Perez Arana <\/strong><\/h2>\n<p>La diabetes mellitus tipo1(dm1) es una patolog\u00eda autoinmune caracterizada por una destrucci\u00f3n de la masa de c\u00e9lulas beta pancre\u00e1ticas por apoptosis mediada por la presencia de citoquinas proinflamatorias (ifn gamma, tnf alfa e il-1 beta) en el p\u00e1ncreas endocrino. este trabajo,utilizando un modelo de roedor con diabetes mellitus espont\u00e1nea autoinmune como la rata bb (biobredding), propone una p\u00e9rdida de la capacidad de respuesta proliferativa de las c\u00e9lulas beta frente a la agresi\u00f3n autoinmune previa al incremento del fen\u00f3meno apopt\u00f3tico. Estando mediada esta p\u00e9rdida al menos parcialmente por la presencia de ifn gamma. por \u00faltimo en este trabajo se propone tambien la utilizaci\u00f3n de un  f\u00e1rmaco estimulador de la proliferaci\u00f3n de las c\u00e9lulas beta como exendina-4 solo o en combinaci\u00f3n con anticuerpos anti-ifn gamma como agente capaz de revertir parcialmente la p\u00e9rdida de capacidad proliferativa de las c\u00e9lulas beta observada en estadios tempranos de la insulitis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Importancia del incremento de la apoptosis e inhibici\u00f3n de la proliferaci\u00f3n de la c\u00e9lula beta en la patogenia de la diabetes mellitus autoinmune<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Importancia del incremento de la apoptosis e inhibici\u00f3n de la proliferaci\u00f3n de la c\u00e9lula beta en la patogenia de la diabetes mellitus autoinmune <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo Perez Arana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Aguilar Diosdado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ana Mar\u00eda Navarro arevalo <\/li>\n<li>german Manuel Perdomo hernandez (vocal)<\/li>\n<li>Fernando Cardona diaz (vocal)<\/li>\n<li>Manuel Carrasco vi\u00f1uela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo Perez Arana La diabetes mellitus tipo1(dm1) es una patolog\u00eda autoinmune caracterizada por una destrucci\u00f3n de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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