{"id":97537,"date":"2018-03-11T10:18:03","date_gmt":"2018-03-11T10:18:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/immune-profiling-of-operational-tolerance-in-liver-transplantation\/"},"modified":"2018-03-11T10:18:03","modified_gmt":"2018-03-11T10:18:03","slug":"immune-profiling-of-operational-tolerance-in-liver-transplantation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/immune-profiling-of-operational-tolerance-in-liver-transplantation\/","title":{"rendered":"Immune profiling of operational tolerance in liver transplantation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marc Mart\u00ednez Llordella <\/strong><\/h2>\n<p>La aceptaci\u00f3n indefinida de los \u00f3rganos trasplantados, manteniendo el correcto funcionamiento del injerto sin la necesidad de administrar el agresivo tratamiento inmunosupresor, constituye el principal objetivo de la investigaci\u00f3n cl\u00ednica en el campo del trasplante. Aunque este fen\u00f3meno se observa con frecuencia en modelos animales, la tolerancia inmunol\u00f3gica al injerto en seres humanos se reduce a un limitado grupo de pacientes, principalmente trasplantados hep\u00e1ticos, considerados tolerantes operacionales.   el objetivo del estudio es precisamente la caracterizaci\u00f3n inmunol\u00f3gica de los pacientes operacionalmente tolerantes despu\u00e9s del trasplante de h\u00edgado. El an\u00e1lisis descriptivo de distintos par\u00e1metros inmunol\u00f3gicos en sangre perif\u00e9rica mediante citometria de flujo y expresi\u00f3n gen\u00e9tica permiti\u00f3 delimitar la contribuci\u00f3n de las principales subpoblaciones inmunol\u00f3gicas en la aceptaci\u00f3n del injerto hep\u00e1tico y los posibles mecanismos moleculares responsables del proceso de tolerancia.   los receptores hep\u00e1ticos tolerantes mostraron un mayor n\u00famero de linfocitos reguladores cd4+cd25+cd62lhigh foxp3+ que los pacientes no tolerantes, pero no que los controles sanos, evidenciando la posible interacci\u00f3n de los f\u00e1rmacos inmunosupresores con los linfocitos t reguladores. Asimismo, los pacientes tolerantes exhib\u00edan una proporci\u00f3n de linfocitos gammadelta superior y una inversi\u00f3n del cociente de las subpoblaciones delta1+\/delta 2+ respeto a los receptores dependientes de inmunosupresi\u00f3n y a los controles, consecuencia de la expansi\u00f3n del subtipo linfocitario vdelta1.   el an\u00e1lisis de expresi\u00f3n gen\u00e9tica de sangre perif\u00e9rica manifest\u00f3 diferencias significativas en el patr\u00f3n de expresi\u00f3n de los pacientes tolerantes respeto a los receptores no tolerantes y controles sanos. Estos cambios transcripcionales fueron validados con muestras independientes empleando pcr a tiempo real y a nivel proteico mediante citometria de flujo. Los resultados revelaron un incremento de expresi\u00f3n de genes relacionados con c\u00e9lulas nk y linfocitos gammadelta, sugiriendo un papel central del sistema inmune innato en el mantenimiento del estado de tolerancia.  el estudio realizado no solo proporciona un mayor conocimiento de los mecanismos relacionados en la tolerancia hep\u00e1tica, tambi\u00e9n sugiere que el uso de biomarcadores, como el patr\u00f3n de expresi\u00f3n gen\u00e9tica en sangre perif\u00e9rica, podr\u00eda ser usado como test diagnostico en la pr\u00e1ctica cl\u00ednica para identificar receptores tolerantes a quienes se les puede retirar la terapia inmunosupresora.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Immune profiling of operational tolerance in liver transplantation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Immune profiling of operational tolerance in liver transplantation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marc Mart\u00ednez Llordella <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Sanchez Fueyo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Mar\u00eda Griny\u00f3 boira <\/li>\n<li>jordi Cano ochando (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marc Mart\u00ednez Llordella La aceptaci\u00f3n indefinida de los \u00f3rganos trasplantados, manteniendo el correcto funcionamiento del injerto sin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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