{"id":97596,"date":"2018-03-11T10:18:07","date_gmt":"2018-03-11T10:18:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-y-significado-clinico-de-las-metaloproteasas-y-sus-inhibidores-en-los-ganglios-linfaticos-axilares-metastasicos-del-cancer-de-mama\/"},"modified":"2018-03-11T10:18:07","modified_gmt":"2018-03-11T10:18:07","slug":"expresion-y-significado-clinico-de-las-metaloproteasas-y-sus-inhibidores-en-los-ganglios-linfaticos-axilares-metastasicos-del-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/expresion-y-significado-clinico-de-las-metaloproteasas-y-sus-inhibidores-en-los-ganglios-linfaticos-axilares-metastasicos-del-cancer-de-mama\/","title":{"rendered":"Expresion y significado clinico de las metaloproteasas y sus inhibidores en los ganglios linfaticos axilares metastasicos del cancer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Fernanda Garcia Diaz <\/strong><\/h2>\n<p>El objetivo del estudio fue investigar la expresi\u00f3n de las metaloproteasas (mmps) y sus inhibidores (timps) en los ganglios linf\u00e1ticos axilares neopl\u00e1sicos (glans) de pacientes con c\u00e1ncer de mama. Se realiz\u00f3 un estudio inmunohistoqu\u00edmico de la expresi\u00f3n de las mmps-1,2,7,9,11,13,14 y timps-1,2,3, en los tumores primarios y glams, correspondientes a 39 pacientes. La expresi\u00f3n global (valores de score) de mmp-1,7 y 14, timp-1,2 y 3, fueron significativamente mas altas en el centro del tumor que en la frontera invasiva o en los glans. Las expresiones de mmp-7 y 14, timp-3, por los fibroblastos y c\u00e9lulas mononucleares inflamatorias (cmis) en los glans fueron significativamente m\u00e1s elevadas que en las otras localizaciones. Adem\u00e1s, las expresiones de mmp-11 y timp-1 y 2 por las cmis, as\u00ed como la expresi\u00f3n de timp-2 por los fibroblastos en el centro tumoral, fueron significativamente asociadas con el desarrollo de met\u00e1stasis a distancia. Adem\u00e1s, nuestros resultados demostraron que la expresi\u00f3n e timp-1 por los fibroblastos en la frontera invasiva fue significativamente asociada con un mal pron\u00f3stico. Sin embargo, ninguna de esas expresiones en los glans fueron asociados con el desarrollo de met\u00e1stasis. Pero las expresiones de mmp-1, 7, 9, 13 y 14, y timp-1 en los glans fueron asociados con una alta probabilidad de la afectaci\u00f3n tumoral de mas de uno o dos ganglios. Nuestros resultados indican que cambios significativos en las expresiones de esos factores entre los tumores primarios y los glans, pueden ser de importancia para conocer la evoluci\u00f3n del c\u00e1ncer de mama a trav\u00e9s de sus diferentes localizaciones.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion y significado clinico de las metaloproteasas y sus inhibidores en los ganglios linfaticos axilares metastasicos del cancer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion y significado clinico de las metaloproteasas y sus inhibidores en los ganglios linfaticos axilares metastasicos del cancer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Fernanda Garcia Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Jose Vizoso  Pi\u00f1eiro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Ferrer barriendos <\/li>\n<li>rom\u00e1n P\u00e9rez fern\u00e1ndez (vocal)<\/li>\n<li>Mar\u00eda  luz Lamelas suarez-pola (vocal)<\/li>\n<li>Jos\u00e9 Schneider fontan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Fernanda Garcia Diaz El objetivo del estudio fue investigar la expresi\u00f3n de las metaloproteasas (mmps) y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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