{"id":97605,"date":"2018-03-11T10:18:11","date_gmt":"2018-03-11T10:18:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-de-las-moleculas-de-adhesion-del-complejo-cadherina-catenina-en-el-nefroblastoma\/"},"modified":"2018-03-11T10:18:11","modified_gmt":"2018-03-11T10:18:11","slug":"estudio-de-la-expresion-de-las-moleculas-de-adhesion-del-complejo-cadherina-catenina-en-el-nefroblastoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/estudio-de-la-expresion-de-las-moleculas-de-adhesion-del-complejo-cadherina-catenina-en-el-nefroblastoma\/","title":{"rendered":"Estudio de la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n del complejo cadherina-catenina en el nefroblastoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marco Antonio Ponce Camacho <\/strong><\/h2>\n<p>El nefroblastoma es el tumor renal pedi\u00e1trico m\u00e1s frecuente. Tanto las caracter\u00edsticas fenot\u00edpicas como las moleculares son heterog\u00e9neas. En este estudio, se ha evaluado un grupo de 45 casos de nefroblastoma. Se realizaron nuevas preparaciones te\u00f1idas con hematoxilina y eosina de todos los casos y se analizaron para corroborar el diagn\u00f3stico de nefroblastoma y, as\u00ed, poder escoger el material adecuado para ser sometido a estudio. Todos los casos mostraron la histolog\u00eda trif\u00e1sica que se describe en los nefroblastomas cl\u00e1sicos, cada uno de los componentes celulares tumorales estuvo presente en diferentes proporciones. La mayor\u00eda de los nefroblastomas estudiados (44) fueron de histolog\u00eda favorable y s\u00f3lo un caso exhibi\u00f3 los hallazgos t\u00edpicos de la histolog\u00eda desfavorable descritos en el nefroblastoma (gigantismo nuclear y mitosis multipolares). El patr\u00f3n blastemal fue el que m\u00e1s predomin\u00f3 (53,3%) seguido por el patr\u00f3n epitelial (31,1%), el cual estaba representado por t\u00fabulos en diferentes grados de maduraci\u00f3n, as\u00ed como por presencia de estructuras papilares y estructuras glomeruloides muy semejantes a lo observado en el ri\u00f1\u00f3n en desarrollo. El tercer patr\u00f3n de crecimiento en orden de frecuencia fue el estromal (15,6%), representado por tejido desde fibroso inmaduro hasta musculo estriado esquel\u00e9tico. este estudio ha investigado una serie de mol\u00e9culas del sistema de adhesi\u00f3n celular cadherina-beta-catenina. Se han corrido seis mol\u00e9culas de adhesi\u00f3n consistentes en cadherina-p, cadherina-e, alfa-catenina, beta-catenina, p120 y gama-catenina. Tambi\u00e9n se obtuvo el \u00edndice de proliferaci\u00f3n celular mediante el inmunomarcador ki67. el ep\u00edtope cadherina-e mostr\u00f3 positividad membranosa predominantemente en el componente epitelial de los tumores estudiados. La mayor\u00eda de los nefroblastomas fueron positivos para adhesi\u00f3n alfa-catenina, gama-catenina, y p120. El patr\u00f3n estromal no mostr\u00f3 reactividad para cadherina-e. La falta de expresi\u00f3n de cadherina-e facilita la invasi\u00f3n tumoral. La falta de expresi\u00f3n de cadherina-e no parece alterar la regulaci\u00f3n de sus mol\u00e9culas asociadas: (alfa-catenina, beta-catenina, gama-catenina y p120).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n del complejo cadherina-catenina en el nefroblastoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n del complejo cadherina-catenina en el nefroblastoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marco Antonio Ponce Camacho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Alonso Hardisson Hernaez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Nistal mart\u00edn de serrano <\/li>\n<li>Miguel \u00e1ngel Mart\u00ednez  gonz\u00e1lez (vocal)<\/li>\n<li>\u00e1lvaro Serrano pascual (vocal)<\/li>\n<li>Emilio Mayayo artal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marco Antonio Ponce Camacho El nefroblastoma es el tumor renal pedi\u00e1trico m\u00e1s frecuente. Tanto las caracter\u00edsticas fenot\u00edpicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[347,384],"tags":[15451,44310,89993,14272,199928,139495],"class_list":["post-97605","post","type-post","status-publish","format-standard","hentry","category-oncologia-clinica","category-patologia-clinica","tag-alvaro-serrano-pascual","tag-david-alonso-hardisson-hernaez","tag-emilio-mayayo-artal","tag-manuel-nistal-martin-de-serrano","tag-marco-antonio-ponce-camacho","tag-miguel-angel-Martinez-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/97605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=97605"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/97605\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=97605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=97605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=97605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}