{"id":97700,"date":"2009-03-12T00:00:00","date_gmt":"2009-03-12T00:00:00","guid":{"rendered":""},"modified":"2009-03-12T00:00:00","modified_gmt":"2009-03-12T00:00:00","slug":"tumores-fibrohistiocitarios-de-la-piel-y-tejidos-blandos-somaticos-estudio-del-comportamiento-biologico-basado-en-el-analisis-inmunohistoqua%c2%admico-del-a%c2%adndice-de-proliferacion-celular-pcna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/tumores-fibrohistiocitarios-de-la-piel-y-tejidos-blandos-somaticos-estudio-del-comportamiento-biologico-basado-en-el-analisis-inmunohistoqua%c2%admico-del-a%c2%adndice-de-proliferacion-celular-pcna\/","title":{"rendered":"Tumores fibrohistiocitarios de la piel y tejidos blandos som\u00e1ticos: estudio del comportamiento biol\u00f3gico basado en el an\u00e1lisis inmunohistoqu\u00edmico del \u00edndice de proliferaci\u00f3n celular (pcna y ki-67) y de la expresi\u00f3n del oncog\u00e9n p53 en 144 casos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Carballo Quint\u00e1 <\/strong><\/h2>\n<p>El objeto de la tesis es el estudio de la correlaci\u00f3n entre la expresi\u00f3n inmunohistoqu\u00edmica del ant\u00edgeno nuclear ki-67 y el ant\u00edgeno nuclear de proliferaci\u00f3n celular (pcna), as\u00ed como la expresi\u00f3n del oncog\u00e9n p53, en diferentes muestras de tejido de tres variedades de tumores fibrohistiocitarios, con la evoluci\u00f3n cl\u00ednica de los pacientes de los cuales han sido obtenidas. Se ha partido de un total de 144 pacientes incluyendo 3 tipos de tumores fibrohistiocitarios abarcando un amplio espectro de malignidad: el fibroxantoma at\u00edpico (considerado cl\u00e1sicamente de baja malignidad), el dermatofibrosarcoma protuberans (de malignidad intermedia o borderline) y el histiocitoma fibroso maligno (de alta malignidad). Se utiliza el anticuerpo monoclonal mib-1 para la detecci\u00f3n de ki-67 y pc-10 para la detecci\u00f3n de pcna, dado que ambos son anticuerpos que permiten detectar el ant\u00edgeno correspondiente en tejidos fijados en formol e incluidos en parafina, tal y como se presentan en el banco de muestras del departamento de anatom\u00eda patol\u00f3gica del hospital cl\u00ednico de santiago de compostela.  mediante an\u00e1lisis estad\u00edstico se eval\u00faa la existencia de relaci\u00f3n estad\u00edsticamente significativa entre la intensidad del inmunomarcaje, con cada uno de los marcadores utilizados en las tres estirpes tumorales, y el curso cl\u00ednico a tenor de tres par\u00e1metros de evoluci\u00f3n cl\u00ednica: existencia de recidivas, existencia de met\u00e1stasis y tiempo de supervivencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tumores fibrohistiocitarios de la piel y tejidos blandos som\u00e1ticos: estudio del comportamiento biol\u00f3gico basado en el an\u00e1lisis inmunohistoqu\u00edmico del \u00edndice de proliferaci\u00f3n celular (pcna y ki-67) y de la expresi\u00f3n del oncog\u00e9n p53 en 144 casos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tumores fibrohistiocitarios de la piel y tejidos blandos som\u00e1ticos: estudio del comportamiento biol\u00f3gico basado en el an\u00e1lisis inmunohistoqu\u00edmico del \u00edndice de proliferaci\u00f3n celular (pcna y ki-67) y de la expresi\u00f3n del oncog\u00e9n p53 en 144 casos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Carballo Quint\u00e1 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Teijeiro Vidal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Noya  Garc\u00eda <\/li>\n<li>Miguel angel Ca\u00ednzos fern\u00e1ndez (vocal)<\/li>\n<li>Francisco Jos\u00e9 Martelo villar (vocal)<\/li>\n<li>Francisco V\u00e1zquez fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Carballo Quint\u00e1 El objeto de la tesis es el estudio de la correlaci\u00f3n entre la expresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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