{"id":97802,"date":"2009-09-12T00:00:00","date_gmt":"2009-09-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-ablacion-restringida-de-la-corteza-auditiva-sobre-el-cola%c2%adculo-inferior-en-la-rata\/"},"modified":"2009-09-12T00:00:00","modified_gmt":"2009-09-12T00:00:00","slug":"efectos-de-la-ablacion-restringida-de-la-corteza-auditiva-sobre-el-cola%c2%adculo-inferior-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/efectos-de-la-ablacion-restringida-de-la-corteza-auditiva-sobre-el-cola%c2%adculo-inferior-en-la-rata\/","title":{"rendered":"Efectos de la ablaci\u00f3n restringida de la corteza auditiva sobre el col\u00edculo inferior en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cheryl Clarkson Paredes <\/strong><\/h2>\n<p>El col\u00edculo inferior es un n\u00facleo de convergencia para la inmensa mayor\u00eda de las se\u00f1ales auditivas ascendentes, que utilizan diferentes tipos de neurotransmisores y la proyecci\u00f3n auditiva cortico-colicular descendente, adem\u00e1s cuenta con un denso sistema de fibras comisurales e intr\u00ednsecas que interconectan ambos col\u00edculos y sus tres subdivisiones entre s\u00ed.  As\u00ed la deaferentaci\u00f3n de la proyecci\u00f3n cortico-colicular que utiliza el glutamato como neurotransmisor produce una p\u00e9rdida del balance entre la inhibici\u00f3n y la excitaci\u00f3n sobre este n\u00facleo, que es evaluable tras largos per\u00edodos de tiempo postlesi\u00f3n.              en esta investigaci\u00f3n se demuestra, utilizando pruebas funcionales como son los potenciales evocados del tronco encef\u00e1lico y el reflejo auditivo del sobresalto\/inhibici\u00f3n por est\u00edmulo previo, que la lesi\u00f3n unilateral por ablaci\u00f3n de la corteza auditiva de la rata provoca una p\u00e9rdida de la actividad de \u00e9sta v\u00eda auditiva, basada principalmente en el bloqueo de la s\u00edntesis de los receptores ionotr\u00f3picos de glutamato que conduce a una alteraci\u00f3n en las concentraciones intracelulares de calcio en la neuronas coliculares deaferentadas, produciendo adem\u00e1s alteraciones en la expresi\u00f3n de genes como c-fos y prote\u00ednas como la calretinina implicadas en la actividad y modulaci\u00f3n de la excitabilidad neuronal respectivamente.  Podemos entonces concluir que este n\u00facleo cuenta con los mecanismos necesarios para reaccionar tras largos per\u00edodos de tiempo postlesi\u00f3n compensando las alteraciones inducidas mediante  procesos reparativos que comparten caracter\u00edsticas compatibles con fen\u00f3menos de plasticidad homeost\u00e1tica (quantal scaling de receptores ionotr\u00f3picos de glutamato) y un re-equilibrio del calcio.  Estos cambios, entre otros posibles, ocasionan la reactivaci\u00f3n funcional del sistema auditivo, pudiendo considerarse como procesos de plasticidad neuronal a largo plazo. Los resultados de esta tesis doctoral  avalan la existencia de un potencial pl\u00e1stico o reorganizativo en el sistema nervioso auditivo de los animales adultos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la ablaci\u00f3n restringida de la corteza auditiva sobre el col\u00edculo inferior en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la ablaci\u00f3n restringida de la corteza auditiva sobre el col\u00edculo inferior en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cheryl Clarkson Paredes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Merchan Cifuentes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Yajeya p\u00e9rez <\/li>\n<li>Juan  Carlos Alvarado romero (vocal)<\/li>\n<li>isabel Varela nieto (vocal)<\/li>\n<li>victoria m. Bajo lorenzana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cheryl Clarkson Paredes El col\u00edculo inferior es un n\u00facleo de convergencia para la inmensa mayor\u00eda de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,2008,9386],"tags":[200246,44785,5704,37287,9729,196701],"class_list":["post-97802","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-morfologia-celular","category-salamanca","tag-cheryl-clarkson-paredes","tag-isabel-varela-nieto","tag-javier-yajeya-perez","tag-juan-carlos-alvarado-romero","tag-miguel-angel-merchan-cifuentes","tag-victoria-m-bajo-lorenzana"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/97802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=97802"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/97802\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=97802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=97802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=97802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}