{"id":97803,"date":"2009-09-12T00:00:00","date_gmt":"2009-09-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-protea%c2%adna-doblecortina-en-los-procesos-de-neurogenesis-y-migracion-neuronal-en-el-sistema-nervioso-central-adulto\/"},"modified":"2009-09-12T00:00:00","modified_gmt":"2009-09-12T00:00:00","slug":"papel-de-la-protea%c2%adna-doblecortina-en-los-procesos-de-neurogenesis-y-migracion-neuronal-en-el-sistema-nervioso-central-adulto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histologia-animal\/papel-de-la-protea%c2%adna-doblecortina-en-los-procesos-de-neurogenesis-y-migracion-neuronal-en-el-sistema-nervioso-central-adulto\/","title":{"rendered":"Papel de la prote\u00edna doblecortina en los procesos de neurog\u00e9nesis y migraci\u00f3n neuronal en el sistema nervioso central adulto"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Vidal  Garc\u00eda <\/strong><\/h2>\n<p>En el presente trabajo hemos estudiado el papel que desempe\u00f1a la prote\u00edna doblecortina en los procesos de proliferaci\u00f3n y migraci\u00f3n neuronal en una regi\u00f3n espec\u00edfica del sistema nervioso central adulto. En este sistema, los neuroblastos se generan el la zona dorsal de los ventr\u00edculos laterales y migran tangencialmente formando cadenas a trav\u00e9s de la ruta denominada corriente migratoria rostral hasta alcanzar el bulbo olfatorio donde migran radialmente y se diferencian a interneuronas que se integran en los circuitos preexistentes. Hemos investigado el papel que ejerce la doblecortina en estos procesos mediante el silenciamiento de su expresi\u00f3n en los neuroblastos y comparando los datos obtenidos con los correspondientes controles. El silenciamiento se llev\u00f3 a cabo mediante arn de interferencia usando como carrier lentivirus con los que se transfectaron in vivo los neuroblastos migrantes. hemos demostrado que la ausencia de doblecortina no afecta al proceso de migraci\u00f3n tangencial mientras que si lo hace sobre la migraci\u00f3n radial. As\u00ed, se produce un enlentecimiento de la migraci\u00f3n radial en el bulbo olfatorio, acumul\u00e1ndose los neuroblastos en las regiones m\u00e1s profundas del mismo. Tambi\u00e9n se produce un enlentecimiento en el proceso de diferenciaci\u00f3n de los neuroblastos que alcanzan el bulbo olfatorio, detect\u00e1ndose adem\u00e1s, en estas neuronas \u00e1rboles dendr\u00edticos de menor tama\u00f1o, m\u00e1s tortuosos y con espinas dendr\u00edticas y g\u00e9mulas menos desarrolladas. estos resultados demuestran que la expresi\u00f3n de doblecortina no es tan decisiva para el correcto desarrollo de los procesos de migraci\u00f3n en el sistema nervioso central adulto como lo es en el desarrollo embrionario, pero constituye un factor importante para que este proceso se tenga lugar con normalidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la prote\u00edna doblecortina en los procesos de neurog\u00e9nesis y migraci\u00f3n neuronal en el sistema nervioso central adulto<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la prote\u00edna doblecortina en los procesos de neurog\u00e9nesis y migraci\u00f3n neuronal en el sistema nervioso central adulto <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Vidal  Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Mar\u00eda Garcia Bri\u00f1on<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Aijon noguera <\/li>\n<li>Carlos Crespo ruperez (vocal)<\/li>\n<li>Jorge Valero gomez-lobo (vocal)<\/li>\n<li>Antonio Talavera diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Vidal Garc\u00eda En el presente trabajo hemos estudiado el papel que desempe\u00f1a la prote\u00edna doblecortina en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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