{"id":97822,"date":"2009-10-12T00:00:00","date_gmt":"2009-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibidores-del-enzima-deshidroquinasa-para-el-desarrollo-de-nuevos-antimicrobianos\/"},"modified":"2009-10-12T00:00:00","modified_gmt":"2009-10-12T00:00:00","slug":"inhibidores-del-enzima-deshidroquinasa-para-el-desarrollo-de-nuevos-antimicrobianos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/enzimologia\/inhibidores-del-enzima-deshidroquinasa-para-el-desarrollo-de-nuevos-antimicrobianos\/","title":{"rendered":"Inhibidores del enzima deshidroquinasa para el desarrollo de nuevos antimicrobianos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ver\u00f3nica Filipa Vieira Prazeres <\/strong><\/h2>\n<p>En la mayor\u00eda de los pa\u00edses europeos, los antibi\u00f3ticos son el segundo tipo de medicamentos m\u00e1s usados despu\u00e9s de los analg\u00e9sicos. Su utilizaci\u00f3n en exceso, y en muchos casos inapropiado, tanto en medicina, en veterinaria y en agricultura, ha dado lugar a la creciente aparici\u00f3n de cepas resistentes a los medicamentos. De hecho, muchos de los antibi\u00f3ticos habituales, o bien han dejado de ser eficaces, o son mucho menos fiables que cuando se comercializaron por primera vez. Se hace necesario por tanto, descubrir nuevos antibi\u00f3ticos, eficaces y selectivos, con los que se pueda hacer frente a este problema. La selectividad se logra a menudo mediante compuestos que interfieren en rutas biogen\u00e9ticas presentes en los microorganismos. En esta tesis doctoral se aborda la posibilidad de desarrollar nuevos antibi\u00f3ticos, cuya acci\u00f3n se basa en la inhibici\u00f3n selectiva y eficaz de la ruta del \u00e1cido siqu\u00edmico, una ruta esencial en los microorganismos. En concreto, se han desarrollado diversos inhibidores competitivos del tercer enzima de esta v\u00eda biosint\u00e9tica, la deshidroquinasa. Se han dise\u00f1ado y sintetizado inhibidores capaces de competir por el sustrato natural y otros que son an\u00e1logos del intermedio de la reacci\u00f3n catalizada por la deshidroquinasa. Estos estudios han permitido identificar varios inhibidores con actividad en el rango nanomolar, cuya actividad es muy superior a los anteriormente descritos en bibliograf\u00eda, y lo que es m\u00e1s importante, frente a bacterias pat\u00f3genas de gran inter\u00e9s terap\u00e9utico, en concreto, mycobacterium tuberculosis (bacteria causante de la tuberculosis) y helicobacter pylori (responsable del c\u00e1ncer de est\u00f3mago). Adem\u00e1s se han realizado diversos estudios estructurales (rmn, difracci\u00f3n de rayos x, fluorescencia) para el conocimiento del modo de uni\u00f3n de dichos inhibidores en el centro activo de la deshidroquinasa, y que han permitido determinar las interacciones claves del inhibidor con dos residuos esenciales del enzima, una tirosina y una arginina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inhibidores del enzima deshidroquinasa para el desarrollo de nuevos antimicrobianos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inhibidores del enzima deshidroquinasa para el desarrollo de nuevos antimicrobianos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ver\u00f3nica Filipa Vieira Prazeres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepci\u00f3n Gonz\u00e1lez Bello<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  jose Camarasa rius <\/li>\n<li>Jos\u00e9 abrunheiro Da silva cavaleiro (vocal)<\/li>\n<li>Ana Mar\u00eda Lobo (vocal)<\/li>\n<li>Francisco Javier Ca\u00f1ada vicinay (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ver\u00f3nica Filipa Vieira Prazeres En la mayor\u00eda de los pa\u00edses europeos, los antibi\u00f3ticos son el segundo tipo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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