{"id":97831,"date":"2009-10-12T00:00:00","date_gmt":"2009-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hiperproduccion-de-la-cefalosporinasa-cromosomica-ampc-en-pseudomonas-aeruginosa-efecto-sobre-el-fitness-y-caracterizacion-de-nuevos-mecanismos-de-resistencia-a-b-lactamicos\/"},"modified":"2009-10-12T00:00:00","modified_gmt":"2009-10-12T00:00:00","slug":"hiperproduccion-de-la-cefalosporinasa-cromosomica-ampc-en-pseudomonas-aeruginosa-efecto-sobre-el-fitness-y-caracterizacion-de-nuevos-mecanismos-de-resistencia-a-b-lactamicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/hiperproduccion-de-la-cefalosporinasa-cromosomica-ampc-en-pseudomonas-aeruginosa-efecto-sobre-el-fitness-y-caracterizacion-de-nuevos-mecanismos-de-resistencia-a-b-lactamicos\/","title":{"rendered":"Hiperproducci\u00f3n de la cefalosporinasa cromos\u00f3mica ampc en pseudomonas aeruginosa: efecto sobre el fitness y caracterizaci\u00f3n de nuevos mecanismos de resistencia a b-lact\u00e1micos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bartolom\u00e9 Moy\u00e1 Ca\u00f1ellas <\/strong><\/h2>\n<p>Resum la hiperproducci\u00f3 de la cefalosporinasa cromoss\u00ed\u00b2mica ampc de pseudomonas aeruginosa, \u00e9s el mecanisme m\u00e9s prevalent (20%) de resist\u00e9ncia a betalact\u00ed\u00a0mics, un dels majors problemes de resist\u00e9ncia antibi\u00ed\u00b2tica sobretot a les unitats de cures intensives. El mecanisme pel qual es regula aquest enzim (\u00edntimament lligat al reciclatge del peptidglic\u00ed\u00a0) i per tant els gens responsables de la seva hiperproducci\u00f3 no estan plenament caracteritzats, aix\u00ed com l\u00c2\u00bfefecte que t\u00e9 a la regulaci\u00f3 i fitness d\u00c2\u00bfaquest microorganisme. Aquests foren els objectius d\u00c2\u00bfaquesta tesi. la hiperproducci\u00f3 constitutiva de la cefalosporinasa ampc, degut a la inactivaci\u00f3 seq\u00ed\u00bcencial de les tres amidases que actuen com a repressors, comporta una dr\u00ed\u00a0stica reducci\u00f3 del fitness degut a la acumulaci\u00f3 citoplasm\u00ed\u00a0tica de murop\u00e9ptids. Per tant aquest no seria un mecanisme viable per a l\u00c2\u00bfobtenci\u00f3 de resist\u00e9ncia d\u00c2\u00bfalt nivell a betalact\u00ed\u00a0mics.  no obstant aix\u00ed\u00b2, la inactivaci\u00f3 mutacional de la pbp4, descrita per primera vegada a n\u00c2\u00bf aquest treball, determina resist\u00e9ncia d\u00c2\u00bfalt nivell als betalact\u00ed\u00a0mics, sense minvar el fitness  ni la capacitat virulenta d\u00c2\u00bfaquest microorganisme.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hiperproducci\u00f3n de la cefalosporinasa cromos\u00f3mica ampc en pseudomonas aeruginosa: efecto sobre el fitness y caracterizaci\u00f3n de nuevos mecanismos de resistencia a b-lact\u00e1micos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hiperproducci\u00f3n de la cefalosporinasa cromos\u00f3mica ampc en pseudomonas aeruginosa: efecto sobre el fitness y caracterizaci\u00f3n de nuevos mecanismos de resistencia a b-lact\u00e1micos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bartolom\u00e9 Moy\u00e1 Ca\u00f1ellas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Illes balears<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Oliver Palomo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Martinez Martinez <\/li>\n<li>Jos\u00e9 lu\u00eds Mart\u00ednez men\u00e9ndez (vocal)<\/li>\n<li>german Bou  arevalo (vocal)<\/li>\n<li>Juan  alfonso Ayala serrano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bartolom\u00e9 Moy\u00e1 Ca\u00f1ellas Resum la hiperproducci\u00f3 de la cefalosporinasa cromoss\u00ed\u00b2mica ampc de pseudomonas aeruginosa, \u00e9s el mecanisme [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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