{"id":97884,"date":"2009-11-12T00:00:00","date_gmt":"2009-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/the-development-of-the-neurosensory-elements-of-the-inner-ear-the-role-of-sox2-and-notch-signalling\/"},"modified":"2009-11-12T00:00:00","modified_gmt":"2009-11-12T00:00:00","slug":"the-development-of-the-neurosensory-elements-of-the-inner-ear-the-role-of-sox2-and-notch-signalling","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/the-development-of-the-neurosensory-elements-of-the-inner-ear-the-role-of-sox2-and-notch-signalling\/","title":{"rendered":"The development of the neurosensory elements of the inner ear: the role of sox2 and notch signalling"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joana Mendes Neves <\/strong><\/h2>\n<p>Los experimentos descritos en esta tesis tuvieron por objetivo estudiar la funci\u00f3n de sox2 y serrate1 en el desarrollo de los elementos neurosensoriales del o\u00eddo. En primer lugar describimos el patr\u00f3n de expresi\u00f3n de sox2 durante el desarrollo del o\u00eddo y lo comparamos con el de sox3 y serrate1. En segundo lugar, mostramos los resultados de experimentos de electroporaci\u00f3n in ovo, dise\u00f1ados para manipular ex\u00f3genamente la expresi\u00f3n g\u00e9nica y estudiar la ganancia de funci\u00f3n de sox2 y serrate1. Los efectos sobre el destino celular y las dianas moleculares se analizaron mediante hibridaci\u00f3n in situ, inmunocitoqu\u00edmica y real-time pcr (qrt-pcr).  los resultados muestran que sox2 se expresa en el dominio neurosensoerial del epitelio \u00f3tico durante la fase de neurog\u00e9nesis y, m\u00e1s adelante, durante el desarrollo de los parches prosensoriales y los \u00f3rganos sensoriales. Con la diferenciaci\u00f3n, sox2 es excluido de las neuronas diferenciadas y las c\u00e9lulas ciliadas, pero permanece expresado en las c\u00e9lulas de soporte. Sox3 se coexpresa con sox2 en el dominio neurog\u00e9nico de la copa \u00f3tica. Pero entonces, la expresi\u00f3n de sox3  se reduce y s\u00f3lo sox2 persiste en los precursores sensoriales, en donde se co-expresa con el ligando de notch serrate1. El dominio de expresi\u00f3n de serrate1 est\u00e1 inicialmente contenido en el de sox2, sin embargo, m\u00e1s adelante, sox2 se restringe dentro de los l\u00edmites de serrate1, un proceso que es concomitante con la formaci\u00f3n de los parches sensoriales.  Estos experimentos sugieren que : 1) sox2 se correlaciona con el destino neurosensorial de la placoda \u00f3tica, 2) la neurog\u00e9nesis est\u00e1 asociada con sox2 y sox3, y 3) el desarrollo sensorial est\u00e1 asociado a la expresi\u00f3n de sox2 y serrate1  los estudios de ganancia de funci\u00f3n muestran  que serrate1 regula el destino prosensorial y el desarrollo de los \u00f3rganos sensoriales mediante el mantenimiento de la expresi\u00f3n de sox2 en dominios restringidos del otocisto, sin afectar a la neurog\u00e9nesis. Serrate1 opera en un modo dependiente de notch, consistente con un mecanismo de inducci\u00f3n lateral que comprende la inducci\u00f3n de su propia expresi\u00f3n y la de las dianas de notch hes1, hey1 and hey2. Estudios similares sobre sox2 indican que sox2 especifica el destino neurosensorial en el epitelio \u00f3tico. Sin embargo, las concentraciones altas de sox2 suprimen el destino sensorial y promueven el destino neuronal. Adem\u00e1s, sox2 previene la diferencoiaci\u00f3n celular mediante la cooperaci\u00f3n con notch y bmp.           se propone un modelo en el cual la competencia neural se establece tempranamente en la placoda \u00f3tica mediante la expresi\u00f3n temprana de sox2 y sox3. La cooperaci\u00f3n entre sox2 y sox3 provee una alta concentraci\u00f3n de factores soxb1 que promueven el destino neuronal de los progenitores. En paralelo, serrate1 mantiene la expresi\u00f3n de sox2 en dominios restringidos tras la supresi\u00f3n de sox3. Estos dominios, retienen el potencial neurosensorial y, m\u00e1s adelante, se desarrollan como parches sensoriales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>The development of the neurosensory elements of the inner ear: the role of sox2 and notch signalling<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 The development of the neurosensory elements of the inner ear: the role of sox2 and notch signalling <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joana Mendes Neves <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Gir\u00e1ldez Orgaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Torres sanchez <\/li>\n<li>elisa Mart\u00ed gorostiza (vocal)<\/li>\n<li>nicolas Daudet (vocal)<\/li>\n<li>paul Scotting (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joana Mendes Neves Los experimentos descritos en esta tesis tuvieron por objetivo estudiar la funci\u00f3n de sox2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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