{"id":97888,"date":"2009-11-12T00:00:00","date_gmt":"2009-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-sistemas-ciclohexanicos-nitrogenados-polioxigenados-tetrodotoxinas-y-pancratistatinas\/"},"modified":"2009-11-12T00:00:00","modified_gmt":"2009-11-12T00:00:00","slug":"sa%c2%adntesis-de-sistemas-ciclohexanicos-nitrogenados-polioxigenados-tetrodotoxinas-y-pancratistatinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/sa%c2%adntesis-de-sistemas-ciclohexanicos-nitrogenados-polioxigenados-tetrodotoxinas-y-pancratistatinas\/","title":{"rendered":"S\u00edntesis de sistemas ciclohex\u00e1nicos nitrogenados polioxigenados: tetrodotoxinas y pancratistatinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Cagide Fag\u00edn <\/strong><\/h2>\n<p>Este trabajo de tesis doctoral se centra en los estudios sint\u00e9ticos de compuestos ciclohex\u00e1nicos nitroxenados poliosixenados presentes en un gran n\u00famero de compuestos naturales de gran inter\u00e9s por su actividad biol\u00f3gica, y en particular en la s\u00edntesis de la tetrodotoxina, que posee propiedades analg\u00e9sicas, y la pancratistatina, que posee actividad anticancer\u00edgena. La tal fin, se desaroll\u00f3: a) un procedimiento general para preparaci\u00f3n de beta-(hetero)aril-alfa-nitro-alfa,beta-enales, y b) una nueva metodolog\u00eda de anelaci\u00f3n entre dichos enales y la dimetil-1,3-dioxan-2-ona que permite el ensamblaje del sistema ciclohex\u00e1nico nitrogenado poliosigenado en una \u00fanica etapa. empleando dicha anelaci\u00f3n como una de las etapas llave, desarrollamos una nueva s\u00edntesis formal de la (+\/-)-tetrodotoxina y una s\u00edntesis total pr\u00e1ctica de la (+\/-)-7-desoxi-2-epipancritastatina, as\u00ed como, mediante el empleo de una variante enantioselectiva de la anelaci\u00f3n, una s\u00edntesis total de la (+)-prancritastatina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de sistemas ciclohex\u00e1nicos nitrogenados polioxigenados: tetrodotoxinas y pancratistatinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de sistemas ciclohex\u00e1nicos nitrogenados polioxigenados: tetrodotoxinas y pancratistatinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Cagide Fag\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Alonso Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Delgado cirilo <\/li>\n<li>alicia Boto castro (vocal)<\/li>\n<li>pedro Noheda mart\u00edn (vocal)<\/li>\n<li>Jos\u00e9 Antonio Galvez lafuente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Cagide Fag\u00edn Este trabajo de tesis doctoral se centra en los estudios sint\u00e9ticos de compuestos ciclohex\u00e1nicos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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