{"id":97932,"date":"2009-11-12T00:00:00","date_gmt":"2009-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/linfocitos-t-que-expresan-receptores-nk-en-situaciones-de-activacion-cronica-del-sistema-inmune\/"},"modified":"2009-11-12T00:00:00","modified_gmt":"2009-11-12T00:00:00","slug":"linfocitos-t-que-expresan-receptores-nk-en-situaciones-de-activacion-cronica-del-sistema-inmune","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/linfocitos-t-que-expresan-receptores-nk-en-situaciones-de-activacion-cronica-del-sistema-inmune\/","title":{"rendered":"Linfocitos t que expresan receptores  nk en situaciones de activacion cronica del sistema inmune"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Concepcion Gayoso  Cabada <\/strong><\/h2>\n<p>Las c\u00e9lulas nk son un linaje celular caracterizado por la expresi\u00f3n de receptores encargados de controlar su funci\u00f3n frente a c\u00e9lulas tumorales o infectadas. Estos receptores nk (nkrs) se han encontrado en otros tipos celulares, como c\u00e9lulas nkti y c\u00e9lulas t cd8. Se ha descrito un incremento en la presencia de receptores nk en c\u00e9lulas de ancianos sanos, en c\u00e9lulas que responden a infecciones cr\u00f3nicas o persistentes (cmv o flu) y en ciertas enfermedades autoinmunes. Nuestro trabajo muestra un incremento de los nkrs inhibidores (kir2dl1) y un detrimento de activadores (nkp46, nkp30 y dnam-1) en c\u00e9lulas nk de ancianos. Tambi\u00e9n encontramos un descenso en la capacidad proliferativa de c\u00e9lulas nkti y c\u00e9lulas t espec\u00edficas para virus de individuos ancianos sanos. Igualmente, nuestros estudios muestran un aumento del contenido de perforina en c\u00e9lulas t espec\u00edficas para virus de ancianos. Todas estas alteraciones en el fenotipo y funci\u00f3n de c\u00e9lulas nk, nkti y linfocitos t cd8 espec\u00edficos para virus, podr\u00edan ser la causa del descenso en la funci\u00f3n del sistema inmune y en la respuesta defectuosa a infecciones y a vacunas observada en la poblaci\u00f3n anciana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Linfocitos t que expresan receptores  nk en situaciones de activacion cronica del sistema inmune<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Linfocitos t que expresan receptores  nk en situaciones de activacion cronica del sistema inmune <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Concepcion Gayoso  Cabada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Solana Lara<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li>Javier Garc\u00eda casado (vocal)<\/li>\n<li>olga De la rosa morales (vocal)<\/li>\n<li>M\u00aa raquel Tarazona  lafarga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Concepcion Gayoso Cabada Las c\u00e9lulas nk son un linaje celular caracterizado por la expresi\u00f3n de receptores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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