{"id":97964,"date":"2009-12-12T00:00:00","date_gmt":"2009-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-del-riesgo-cardiovascular-en-los-pacientes-con-enfermedad-osea-de-paget-eop-en-salamanca\/"},"modified":"2009-12-12T00:00:00","modified_gmt":"2009-12-12T00:00:00","slug":"valoracion-del-riesgo-cardiovascular-en-los-pacientes-con-enfermedad-osea-de-paget-eop-en-salamanca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-clinica\/valoracion-del-riesgo-cardiovascular-en-los-pacientes-con-enfermedad-osea-de-paget-eop-en-salamanca\/","title":{"rendered":"Valoraci\u00f3n del riesgo cardiovascular en los pacientes con enfermedad \u00f3sea de paget (eop) en salamanca"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Judit Garcia Aparicio <\/strong><\/h2>\n<p>Introducci\u00f3n: la enfermedad \u00f3sea de paget (eop) se caracterizada por el aumento del recambio \u00f3seo originando un hueso de estructura an\u00e1rquica, que puede generar dolor y deformidades \u00f3seas. La preValencia de la enfermedad aumenta con la edad y seg\u00fan estudios previos, la mortalidad de estos pacientes podr\u00eda ser inferior a la poblaci\u00f3n general. Por otro lado, la primera causa de mortalidad en nuestra comunidad son las enfermedades cardiovasculares (ecv). hip\u00f3tesis \u00ablos pacientes con eop de la serie de salamanca podr\u00edan tener menor riesgo cardiovascular y menos enfermedades cardiovasculares que el resto de la poblaci\u00f3n\u00bb. pacientes y m\u00e9todo se reclutaron 113 pacientes procedentes de la cohorte salmantina de eop y dos grupos control de 226 y 151 individuos para los estudios cl\u00ednicos y gen\u00e9ticos, respectivamente. Se realizaron entrevistas cl\u00ednicas y se recogieron muestras de sangre para determinar niveles de lipoprote\u00edna a, de hs-rcp y estudiar los polimorfismos de los genes mthfr, endotelina 1, il-6, y ppargama. resultados se comprob\u00f3 menor preValencia de hipertensi\u00f3n arterial, diabetes mellitus, colesterol total, colesterol ldl y h\u00e1bito de fumar, que en la poblaci\u00f3n control s\u00f3lo un 11,5% de los pacientes ten\u00edan vida sedentaria. El 10,6 % desarroll\u00f3 alguna ecv. Seg\u00fan las escalas (score, framingham y regicor) s\u00f3lo 2 pacientes fueron clasificados como de alto riesgo cardiovascular (rcv) y el rcv total calculado fue menor que en la poblaci\u00f3n control. El 7 % ten\u00eda los niveles elevados de lipoprote\u00edna (a) y el 21 % de hs-crp, sin encontrar correlaci\u00f3n con el rcv total. El estudio del polimorfismo p12a del gen ppargama mostr\u00f3 el doble de pacientes heterocigotos (cg) que en la poblaci\u00f3n general. conclusiones los pacientes con eop de salamanca tienen menor preValencia de los factores de rcv y de rcv total, que la poblaci\u00f3n general. La mayor preValencia del genotipo cg del polimorfismo p12a del ppar-gamma, puede contribuir a la reducci\u00f3n de los factores de rcv y a su vez estar vinculado con la patog\u00e9nesis de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n del riesgo cardiovascular en los pacientes con enfermedad \u00f3sea de paget (eop) en salamanca<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n del riesgo cardiovascular en los pacientes con enfermedad \u00f3sea de paget (eop) en salamanca <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Judit Garcia Aparicio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>JavierDel Pino Montes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Sosa henr\u00edquez <\/li>\n<li>Jos\u00e9 Luis P\u00e9rez castrill\u00f3n (vocal)<\/li>\n<li>Jos\u00e9 Antonio Riancho moral (vocal)<\/li>\n<li>agustin tomas Vega  alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Judit Garcia Aparicio Introducci\u00f3n: la enfermedad \u00f3sea de paget (eop) se caracterizada por el aumento del recambio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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