{"id":98107,"date":"2018-03-11T10:18:48","date_gmt":"2018-03-11T10:18:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-de-lactogeno-placentario-humano-en-suspensiones-celulares-de-tabaco-escalado-del-proceso-y-produccion-en-biorreactores\/"},"modified":"2018-03-11T10:18:48","modified_gmt":"2018-03-11T10:18:48","slug":"produccion-de-lactogeno-placentario-humano-en-suspensiones-celulares-de-tabaco-escalado-del-proceso-y-produccion-en-biorreactores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/produccion-de-lactogeno-placentario-humano-en-suspensiones-celulares-de-tabaco-escalado-del-proceso-y-produccion-en-biorreactores\/","title":{"rendered":"Producci\u00f3n de lact\u00f3geno placentario humano en suspensiones celulares de tabaco: escalado del proceso y producci\u00f3n en biorreactores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> I\u00f1igo Oyanguren Garcia <\/strong><\/h2>\n<p>La tesis doctoral que se presenta tiene como objetivo establecer un sistema para la producci\u00f3n heter\u00f3loga de lact\u00f3geno placentario humano (hpl) mediante el cultivo de suspensiones celulares transg\u00e9nicas de nicotiana tabacum cv. By2 en biorreactores y bajo condiciones controladas. el lact\u00f3geno placentario humano es una hormona polipept\u00eddica que se sintetiza en la placenta durante el embarazo, y cuya actividad biol\u00f3gica se relaciona con el aumento del n\u00famero de c\u00e9lulas b pancre\u00e1ticas humanas, lo que le confiere una potencialidad terap\u00e9utica en el desarrollo de terapias contra la diabetes. como resultado principal de este trabajo, se han obtenido suspensiones celulares transg\u00e9nicas de tabaco, que producen la prote\u00edna hpl recombinante conservando su actividad biol\u00f3gica. Asimismo, se han determinado los par\u00e1metros de la estrategia de cultivo de las suspensiones con el fin de optimizar la cantidad de prote\u00edna recombinante producida por las c\u00e9lulas. Adem\u00e1s, se ha desarrollado un sistema de expresi\u00f3n que dirige la prote\u00edna a la ruta secretora, haciendo que esta se acumule en el medio de cultivo. Como par\u00e1metros \u00f3ptimos se han obtenido, un in\u00f3culo inicial de 10 gl-1 y un periodo de cultivo de 9 d\u00edas, sometido a una po2 mayor del 20%, una temperatura de 26 \u00c2\u00bac y 180 rpm. En estas condiciones los niveles m\u00e1ximos de prote\u00edna recomb\u00ednate secretada al medio de cultivo se obtienen a los 7 d\u00edas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Producci\u00f3n de lact\u00f3geno placentario humano en suspensiones celulares de tabaco: escalado del proceso y producci\u00f3n en biorreactores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Producci\u00f3n de lact\u00f3geno placentario humano en suspensiones celulares de tabaco: escalado del proceso y producci\u00f3n en biorreactores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 I\u00f1igo Oyanguren Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sonia Casta\u00f1on  De La Torre<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mercedes Renobales scheifler <\/li>\n<li>Jos\u00e9 Mar\u00eda Torne cubiro (vocal)<\/li>\n<li>Juan  evaristo Suarez fernandez (vocal)<\/li>\n<li>ricardo Javier Ordas fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de I\u00f1igo Oyanguren Garcia La tesis doctoral que se presenta tiene como objetivo establecer un sistema para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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