{"id":98153,"date":"2018-03-11T10:18:53","date_gmt":"2018-03-11T10:18:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/crecimiento-en-un-modelo-experimental-de-deficit-cronico-de-potasio\/"},"modified":"2018-03-11T10:18:53","modified_gmt":"2018-03-11T10:18:53","slug":"crecimiento-en-un-modelo-experimental-de-deficit-cronico-de-potasio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pediatria\/crecimiento-en-un-modelo-experimental-de-deficit-cronico-de-potasio\/","title":{"rendered":"Crecimiento en un modelo experimental de d\u00e9ficit cr\u00f3nico de potasio."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Gil Pe\u00f1a <\/strong><\/h2>\n<p>Para investigar los mecanismos responsables del hipocrecimiento en las tubulopat\u00edas hipopotas\u00e9micas, se analizaron en un modelo experimental de d\u00e9ficit de potasio: estructura y din\u00e1mica de la placa de crecimiento de los huesos largos,  el tejido renal, eje hormona de crecimiento &#8211; factor de crecimiento similar a la insulina i (gh-igf-i) y efecto del tratamiento con gh. Se estudiaron cuatro grupos (n=10) de ratas j\u00f3venes: dieta normal (c), dieta deficiente en potasio (dk); dk tratadas con gh (dkgh); dieta normal en cantidad pareada con dk (cpf). Tras 14 d\u00edas, se midi\u00f3 ganancia de peso, velocidad de crecimiento longitudinal por el avance del frente \u00f3seo (afo), equilibrio \u00e1cido-base y potasio e igf-i s\u00e9ricos; histomorfometr\u00eda, \u00edndice de proliferaci\u00f3n de los condrocitos y actividad osteocl\u00e1stica en placa de crecimiento;  niveles de arnm de igf-i y de los receptores de gh e igf-i en placa de crecimiento e h\u00edgado. Los grupos dk y dkgh desarrollaron alcalosis metab\u00f3lica hipopotas\u00e9mica. Los animales dk fueron hipocrecidos presentando marcadas alteraciones en la hipertrofia y maduraci\u00f3n de los condrocitos, con menor altura (x\u00c2\u00b1de) de los condrocitos terminales (20,8\u00c2\u00b12,4 vs 23,5\u00c2\u00b14,8 y 24,2\u00c2\u00b15,9 \u00c2\u00b5m en c y cpf). Las ratas dk tuvieron valores de igf-i circulante similarmente descendidos al grupo cpf y, en comparaci\u00f3n con los controles, sobreexpresi\u00f3n del receptor de gh (1,53\u00c2\u00b10,14) e inhibici\u00f3n del igf-i (0,60\u00c2\u00b10,09) en la placa de crecimiento, indicando resistencia a la acci\u00f3n de la gh end\u00f3gena  por defectos postreceptoriales. El tratamiento con gh mejor\u00f3 el peso pero no la velocidad de crecimiento (77,7\u00c2\u00b19,8 vs 67,1\u00c2\u00b110,4 \u00c2\u00b5m en dk) ni el anormal proceso de hipertrofia de los condrocitos (21,6\u00c2\u00b12,6 \u00c2\u00b5m). Esta falta de est\u00edmulo del crecimiento longitudinal se asoci\u00f3 en la placa de crecimiento con una menor expresi\u00f3n de igf-i (0,57\u00c2\u00b10,10) a pesar de estar sobreexpresado el receptor de gh (1,79\u00c2\u00b10,15). El tratamiento con gh aument\u00f3 el arnm hep\u00e1tico de igf-i (2,101\u00c2\u00b10,03) aunque no el igf-i circulante indicando un defecto postranscripcional y\/o una disminuci\u00f3n de la vida media del igf-i en sangre como mecanismos endocrinos responsables de la resistencia a la gh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Crecimiento en un modelo experimental de d\u00e9ficit cr\u00f3nico de potasio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Crecimiento en un modelo experimental de d\u00e9ficit cr\u00f3nico de potasio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Gil Pe\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Santos Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Cannata andia <\/li>\n<li>victor Manuel Garcia nieto (vocal)<\/li>\n<li>asuncion Lopez calderon barreda (vocal)<\/li>\n<li>f\u00e9lix Claverie mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Gil Pe\u00f1a Para investigar los mecanismos responsables del hipocrecimiento en las tubulopat\u00edas hipopotas\u00e9micas, se analizaron en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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