{"id":98195,"date":"2018-03-11T10:18:53","date_gmt":"2018-03-11T10:18:53","guid":{"rendered":""},"modified":"2018-03-11T10:18:53","modified_gmt":"2018-03-11T10:18:53","slug":"acciones-osteogrenicas-de-la-proteina-relacionada-con-la-parathormona-pthrp-sobre-la-regeneracion-osea-comprometida-por-glucocorticoides-y-en-la-osteoporosis-experimental-por-deplecion-estrogenica-e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/acciones-osteogrenicas-de-la-proteina-relacionada-con-la-parathormona-pthrp-sobre-la-regeneracion-osea-comprometida-por-glucocorticoides-y-en-la-osteoporosis-experimental-por-deplecion-estrogenica-e\/","title":{"rendered":"Acciones osteogrenicas de la proteina relacionada con la parathormona (pthrp) sobre la regeneracion osea comprometida por glucocorticoides y en la osteoporosis experimental por deplecion estrogenica en raton"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Alfonso Fernandez De Castro Diaz <\/strong><\/h2>\n<p>Resumen  la prote\u00edna relacionada con la parathormona (pthrp) es un modulador importante del remodelado y la formaci\u00f3n \u00f3sea. El tratamiento intensivo y\/o prolongado con glucocorticoides (gcs) y la depleci\u00f3n estrog\u00e9nica debida a la menopausia causan una p\u00e9rdida de masa \u00f3sea (osteopenia\/osteoporosis). En la presente tesis doctoral, hemos evaluado y comparado la capacidad del fragmento n-terminal de la pthrp (relacionada con la pth) y de su fragmento c-terminal (no relacionado con esta hormona) para revertir las alteraciones inducidas por los gcs en un modelo de regeneraci\u00f3n \u00f3sea tras la ablaci\u00f3n de m\u00e9dula \u00f3sea; as\u00ed como sus efectos osteog\u00e9nicos en un modelo de osteoporosis postmenop\u00e1usica tras ovariectom\u00eda (ovx) en el rat\u00f3n. Los ratones tratados con 3-metilprednisolona mostraron un retardo en la regeneraci\u00f3n \u00f3sea tras la ablaci\u00f3n medular, asociado a un d\u00e9ficit de formaci\u00f3n y vascularizaci\u00f3n \u00f3sea, y a un incremento en el n\u00famero de osteoclastos y adipocitos. Adem\u00e1s, en este modelo, pudimos observar una p\u00e9rdida de estructura \u00f3sea en el f\u00e9mur intacto. Estos efectos fueron revertidos, al menos en parte, por ambos p\u00e9ptidos de la pthrp. En los ratones ovx, encontramos un aumento de actividad osteocl\u00e1stica, asociada a una disminuci\u00f3n de formaci\u00f3n \u00f3sea, lo  que result\u00f3 en una p\u00e9rdida de masa y estructura \u00f3seas. Ambos fragmentos de la pthrp revirtieron estos cambios, ejerciendo acciones anab\u00f3licas en el hueso osteop\u00e9nico. Adem\u00e1s, en este escenario, el fragmento c-terminal de la pthrp mostr\u00f3 propiedades antirresortivas. en conclusi\u00f3n, estos hallazgos demuestran el papel osteog\u00e9nico de ambos p\u00e9ptidos de la pthrp in vivo, y sugieren su utilizaci\u00f3n como posibles agentes tearp\u00e9uticos para promover la regeneraci\u00f3n \u00f3sea y revertir la p\u00e9rdida de masa y estructura \u00f3seas en la osteoporosis.   abstract  parathyroid hormone-related protein (pthrp) is an important modulator of bone remodelling and bone formation. High and\/or prolonged glucocorticoid (gc) treatment and postmenopausal estrogen depletion lead to bone loss (osteopenia\/osteoporosis). In this doctoral thesis, we assessed and compared the ability of the n-terminal pth-like fragment of pthrp and its pth-unrelated c-terminal fragment to restore the gc-altered bone regeneration after bone marrow (bm) ablation, and their osteogenic effects on an established model of postmenopausal osteoporosis by ovariectomy (ovx) in mice. Treatment with 3-methylprednisolone in mice showed retardation in bone regeneration after bm ablation, associated with decreased bone formation and vascularization but increased osteoclastogenesis and adipogenesis. We also observed an altered bone structure in the intact femur of these gc-treated mice. These effects were reversed, at least in part, by either pthrp peptide. In ovx mice, we found an increased osteoclast activity, associated with a decrease in bone formation, which resulted in a loss of bone mass and structure. Both pthrp fragments reversed these effects, showing anabolic effects in osteopenic bone. The c-terminal fragment of pthrp also showed antirresorptive features in this setting.  in conclusion, these novel findings demonstrate the in vivo osteogenic features of both pthrp peptides, and suggest they could be envisioned as putative therapies to promote bone regeneration and reverse the alterations in bone mass and structure in osteoporosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acciones osteogrenicas de la proteina relacionada con la parathormona (pthrp) sobre la regeneracion osea comprometida por glucocorticoides y en la osteoporosis experimental por deplecion estrogenica en raton<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acciones osteogrenicas de la proteina relacionada con la parathormona (pthrp) sobre la regeneracion osea comprometida por glucocorticoides y en la osteoporosis experimental por deplecion estrogenica en raton <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Alfonso Fernandez De Castro Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Esbrit Arguelles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaqu\u00edn D\u00edaz recasens <\/li>\n<li>adolfo Diez perez (vocal)<\/li>\n<li>julia Bujan varela (vocal)<\/li>\n<li>gabriel Herrero beaumont (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Alfonso Fernandez De Castro Diaz Resumen la prote\u00edna relacionada con la parathormona (pthrp) es un modulador 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