{"id":98236,"date":"2018-03-11T10:18:57","date_gmt":"2018-03-11T10:18:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transporte-de-adenovirus-oncola%c2%adtico-canino-mediado-por-celulas-tumorales-para-el-tratamiento-de-osteosarcoma-canino\/"},"modified":"2018-03-11T10:18:57","modified_gmt":"2018-03-11T10:18:57","slug":"transporte-de-adenovirus-oncola%c2%adtico-canino-mediado-por-celulas-tumorales-para-el-tratamiento-de-osteosarcoma-canino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/virologia\/transporte-de-adenovirus-oncola%c2%adtico-canino-mediado-por-celulas-tumorales-para-el-tratamiento-de-osteosarcoma-canino\/","title":{"rendered":"Transporte de adenovirus oncol\u00edtico canino mediado por c\u00e9lulas tumorales para el tratamiento de osteosarcoma canino"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisca Andrea Alcayaga Miranda <\/strong><\/h2>\n<p>El osteosarcoma es el tumor \u00f3seo m\u00e1s frecuente que afecta al perro. En veterinaria, las opciones para su manejo terap\u00e9utico son limitadas y el pron\u00f3stico para estos pacientes es pobre. Los adenovirus oncol\u00edticos son una atractiva herramienta de tratamiento experimental ya que se pueden replicar y extender dentro del tumor para inducir directamente la destrucci\u00f3n del tejido tumoral. Sin embargo, el mayor impedimento de la administraci\u00f3n sist\u00e9mica de los adenovirus oncol\u00edticos es la presencia de anticuerpos neutralizantes preformados. \u00e9ste obst\u00e1culo puede ser resuelto administrando el adenovirus oncol\u00edtico dentro de una c\u00e9lula transportadora capaz de ocultar los ant\u00edgenos virales durante el transporte sist\u00e9mico. Las c\u00e9lulas tumorales tienen tropismo tumoral, lo que permite su utilizaci\u00f3n como potenciales veh\u00edculos de transporte. En este trabajo, se estudi\u00f3 la capacidad de las c\u00e9lulas tumorales caninas infectadas con adenovirus oncol\u00edtico in vitro y administradas sist\u00e9micamente para escapar de las defensas antivirales, alcanzar el sitio tumoral y, subsecuentemente, de liberar la progenie viral para infectar a la c\u00e9lula tumoral diana en un modelo xenoinjertado de osteosarcoma canino. Los estudios in vivo utilizando c\u00e9lulas tumorales transportadoras demostraron el eficiente transporte sist\u00e9mico de adenovirus oncol\u00edtico al tumor, incluso en presencia de anticuerpos anti-adenovirus. Al contrario, la presencia de anticuerpos anti-adenovirus reducieron el transporte del virus desnudo al tumor. La administraci\u00f3n intratumoral y sist\u00e9mica de las c\u00e9lulas transportadoras infectadas con un adenovirus canino de replicaci\u00f3n selectiva (occav) mostr\u00f3 una disminuci\u00f3n significativa en el crecimiento del tumor comparado con la inyecci\u00f3n del virus desnudo en presencia de altos t\u00edtulos de anticuerpos neutralizantes. La inmunosupresi\u00f3n con ciclofosfamida no afect\u00f3 la actividad terap\u00e9utica de las c\u00e9lulas tumorales infectadas con occav, pero result\u00f3 en un beneficio terap\u00e9utico respecto al virus desnudo. Por otro lado, la administraci\u00f3n intratumoral y sist\u00e9mica de c\u00e9lulas tumorales infectadas con occav en dos perros con osteosarcoma fue bien tolerada. En conjunto, estos hallazgos soportan la idea de la administraci\u00f3n por v\u00eda sist\u00e9mica del sistema celular infectado con virus oncol\u00edtico para el tratamiento del osteosarcoma canino.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Transporte de adenovirus oncol\u00edtico canino mediado por c\u00e9lulas tumorales para el tratamiento de osteosarcoma canino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Transporte de adenovirus oncol\u00edtico canino mediado por c\u00e9lulas tumorales para el tratamiento de osteosarcoma canino <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisca Andrea Alcayaga Miranda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Pastor Mil\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: elena Mart\u00ednez de merlo <\/li>\n<li>Javier Garcia castro (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisca Andrea Alcayaga Miranda El osteosarcoma es el tumor \u00f3seo m\u00e1s frecuente que afecta al perro. En [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,1027,495,280],"tags":[200979,200978,40093,14090],"class_list":["post-98236","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-oncologia","category-patologia-veterinaria","category-virologia","tag-elena-Martinez-de-merlo","tag-francisca-andrea-alcayaga-miranda","tag-javier-garcia-castro","tag-josep-pastor-milan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/98236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=98236"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/98236\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=98236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=98236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=98236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}