{"id":98242,"date":"2018-03-11T10:18:57","date_gmt":"2018-03-11T10:18:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-silenciamiento-de-cd44-y-versicano-en-la%c2%adneas-celulares-de-melanoma-humano\/"},"modified":"2018-03-11T10:18:57","modified_gmt":"2018-03-11T10:18:57","slug":"efecto-del-silenciamiento-de-cd44-y-versicano-en-la%c2%adneas-celulares-de-melanoma-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/efecto-del-silenciamiento-de-cd44-y-versicano-en-la%c2%adneas-celulares-de-melanoma-humano\/","title":{"rendered":"Efecto del silenciamiento de cd44 y versicano en l\u00edneas celulares de melanoma humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Hern\u00e1ndez Mart\u00ednez <\/strong><\/h2>\n<p>El versicano es un proteoglicano de matriz extracelular cuyas isoformas grandes (v0 y v1) han demostrado participar en la regulaci\u00f3n de procesos como la proliferaci\u00f3n, adhesi\u00f3n y migraci\u00f3n celular. Su expresi\u00f3n se ha encontrado en diferentes tipos de c\u00e9lulas tumorales, entre ellos el melanoma. Anteriormente se describi\u00f3 que la expresi\u00f3n de la isoforma peque\u00f1a de versicano (v3) en dos l\u00edneas celulares de melanoma humano (una que expresa las isoformas grandes de versicano de forma end\u00f3gena y otra que no expresa ninguna isoforma) provoca una reversi\u00f3n del fenotipo maligno. En el caso de las c\u00e9lulas que expresan versicano de forma end\u00f3gena, este efecto del versicano v3 se explic\u00f3 por una competencia con dichas isoformas, mientras que en el caso de la l\u00ednea que no expresa versicano la acci\u00f3n de v3 ir\u00eda mediada a trav\u00e9s de una interacci\u00f3n con el receptor de \u00e1cido hialur\u00f3nico cd44. La finalidad de este trabajo ha sido confirmar estas hip\u00f3tesis mediante el silenciamiento por rna de interferencia de la expresi\u00f3n de cd44 y versicano en estas l\u00edneas. Los resultados confirman que la mayor parte de los efectos del versicano v3 tienen lugar a trav\u00e9s de los mecanismos propuestos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del silenciamiento de cd44 y versicano en l\u00edneas celulares de melanoma humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del silenciamiento de cd44 y versicano en l\u00edneas celulares de melanoma humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Hern\u00e1ndez Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Mar\u00eda Bassols Teixido<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  roser Cusso fresquet <\/li>\n<li>angels Fabra fres (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Hern\u00e1ndez Mart\u00ednez El versicano es un proteoglicano de matriz extracelular cuyas isoformas grandes (v0 y v1) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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