{"id":98252,"date":"2018-03-11T10:18:57","date_gmt":"2018-03-11T10:18:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-antiosteoporoticos-de-los-estrogenos-estudio-sobre-las-acciones-del-receptor-de-estrogeno-alfa-en-celulas-de-linaje-osteoclastico\/"},"modified":"2018-03-11T10:18:57","modified_gmt":"2018-03-11T10:18:57","slug":"efectos-antiosteoporoticos-de-los-estrogenos-estudio-sobre-las-acciones-del-receptor-de-estrogeno-alfa-en-celulas-de-linaje-osteoclastico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/efectos-antiosteoporoticos-de-los-estrogenos-estudio-sobre-las-acciones-del-receptor-de-estrogeno-alfa-en-celulas-de-linaje-osteoclastico\/","title":{"rendered":"Efectos antiosteopor\u00f3ticos de los estr\u00f3genos estudio sobre las acciones del receptor de estr\u00f3geno alfa en c\u00e9lulas de linaje osteocl\u00e1stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Martin Millan <\/strong><\/h2>\n<p>El efecto antiosteoporotico de los estr\u00f3genos viene determinado por dos tipos de efectos: efectos indirectos,  a trav\u00e9s de la disminuci\u00f3n de la producci\u00f3n de sustancias pro-inflamatorias producidas por las c\u00e9lulas situadas en la m\u00e9dula \u00f3sea, y efectos directos, a trav\u00e9s de sus receptores en los osteoclastos y osteoblastos. Sin embargo, se desconoce la importancia relativa de cada uno de ellos a la hora de proteger el esqueleto. El objetivo de este trabajo es determinar el papel antiosteoporotico que desarrollan los estr\u00f3genos a trav\u00e9s del receptor de estr\u00f3geno alfa (re\u00c2\u00bf) en los osteoclastos, y establecer si estos efectos son debidos a mecanismos g\u00e9nicos o extrag\u00e9nicos. Para abordar estas cuestiones se ha recurrido a la tecnolog\u00eda loxp y se ha generado un rat\u00f3n en el que se ha deleccionado el re\u00c2\u00bf exclusivamente en c\u00e9lulas de linaje  monocito \/ macr\u00f3fago,  que son las c\u00e9lulas  precursoras de los osteoclastos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos antiosteopor\u00f3ticos de los estr\u00f3genos estudio sobre las acciones del receptor de estr\u00f3geno alfa en c\u00e9lulas de linaje osteocl\u00e1stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos antiosteopor\u00f3ticos de los estr\u00f3genos estudio sobre las acciones del receptor de estr\u00f3geno alfa en c\u00e9lulas de linaje osteocl\u00e1stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Martin Millan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Gonzalez  Macias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Perez cano <\/li>\n<li>Jos\u00e9 Luis Hernandez hernandez (vocal)<\/li>\n<li>Jorge Cannata andia (vocal)<\/li>\n<li>adolfo Diez perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Martin Millan El efecto antiosteoporotico de los estr\u00f3genos viene determinado por dos tipos de efectos: efectos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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