{"id":98365,"date":"2018-03-11T10:19:08","date_gmt":"2018-03-11T10:19:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/importancia-clinica-de-las-celulas-dendriticas-en-el-trasplante-alogenico-de-progenitores-hemopoyeticos\/"},"modified":"2018-03-11T10:19:08","modified_gmt":"2018-03-11T10:19:08","slug":"importancia-clinica-de-las-celulas-dendriticas-en-el-trasplante-alogenico-de-progenitores-hemopoyeticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/importancia-clinica-de-las-celulas-dendriticas-en-el-trasplante-alogenico-de-progenitores-hemopoyeticos\/","title":{"rendered":"Importancia clinica de las celulas dendriticas en el trasplante alogenico de progenitores hemopoyeticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carme Talarn Forcadell <\/strong><\/h2>\n<p>El trasplante alog\u00e9nico de progenitores hemopoy\u00e9ticos da lugar a la sustituci\u00f3n del sistema inmune del paciente por el del donante. Las c\u00e9lulas dendr\u00edticas del donante se integran en el sistema inmunol\u00f3gico del receptor y son b\u00e1sicas en la modulaci\u00f3n de las respuestas inmunes postrasplante.  objetivo: analizar el papel de las dc en el alo-tph y su importancia en el desarrollo de las reacciones aloinmunes despu\u00e9s del trasplante. 1. Cuantificar las dc y los distintos subtipos que se administran al paciente sometido a un alo-tph, comparando las dos fuentes de progenitores, la m\u00e9dula \u00f3sea y la sangre perif\u00e9rica. 2. Analizar el efecto de la administraci\u00f3n de g-csf en donantes sanos sobre  esta poblaci\u00f3n celular. 3. Analizar la asociaci\u00f3n entre las c\u00e9lulas dendr\u00edticas y la aparici\u00f3n de reacciones aloinmunes postrasplante. resultados: de acuerdo con los resultados de la presente tesis doctoral, se ha observado  que la administraci\u00f3n de g-csf en los donantes para la obtenci\u00f3n de progenitores de sp para el alo-tph induce cambios en la cantidad de las subpoblaciones de c\u00e9lulas dendr\u00edticas y en la expresi\u00f3n de mol\u00e9culas reguladoras como el cd86. Esto origina unas modificaciones en la composici\u00f3n del in\u00f3culo administrado al paciente, especialmente de dc cd16+ si comparamos m\u00e9dula \u00f3sea y sangre perif\u00e9rica, lo que podr\u00eda explicar algunas de las diferencias observadas en el alotph de periferia respecto al de m\u00e9dula \u00f3sea. asi mismo este estudio tambi\u00e9n muestra la relaci\u00f3n entre el seguimiento cl\u00ednico y la reconstituci\u00f3n de las dc en el trasplante de intensidad reducida. Por primera vez se  ha establecido la asociaci\u00f3n entre dc cd16+, una poblaci\u00f3n de dc mieloides descrita recientemente, y el seguimiento cl\u00ednico, siendo la reconstituci\u00f3n de esta poblaci\u00f3n a los tres meses el factor independiente m\u00e1s importante en el an\u00e1lisis multivariado de la supervivencia libre de enfermedad (sle).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Importancia clinica de las celulas dendriticas en el trasplante alogenico de progenitores hemopoyeticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Importancia clinica de las celulas dendriticas en el trasplante alogenico de progenitores hemopoyeticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carme Talarn Forcadell <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1lvaro Urbano Ispiz\u00faa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Blade creixenti <\/li>\n<li>salut Brunet mauri (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carme Talarn Forcadell El trasplante alog\u00e9nico de progenitores hemopoy\u00e9ticos da lugar a la sustituci\u00f3n del sistema inmune [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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