{"id":98409,"date":"2018-03-11T10:19:12","date_gmt":"2018-03-11T10:19:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-farmacos-en-diferentes-matrices-biologicas\/"},"modified":"2018-03-11T10:19:12","modified_gmt":"2018-03-11T10:19:12","slug":"determinacion-de-farmacos-en-diferentes-matrices-biologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/determinacion-de-farmacos-en-diferentes-matrices-biologicas\/","title":{"rendered":"Determinaci\u00f3n de f\u00e1rmacos en diferentes matrices biol\u00f3gicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Guerrero Molina <\/strong><\/h2>\n<p>Introducci\u00f3n: la cromatograf\u00eda l\u00edquida de alta eficacia (hplc) es la t\u00e9cnica de referencia en aquellos estudios de investigaci\u00f3n que requieren el an\u00e1lisis de las concentraciones de f\u00e1rmaco y sus metabolitos en tejidos y l\u00edquidos org\u00e1nicos. Su conocimiento proporciona informaci\u00f3n para valorar o predecir la acci\u00f3n terap\u00e9utica o t\u00f3xica del f\u00e1rmaco y es una buena herramienta para la selecci\u00f3n de las dosis \u00f3ptimas de f\u00e1rmaco de manera individualizada por paciente y para una patolog\u00eda determinada. hip\u00f3tesis: i)  el desarrollo, puesta a punto y validaci\u00f3n de t\u00e9cnicas cromatogr\u00e1ficas permiten la determinaci\u00f3n y cuantificaci\u00f3n de las concentraciones de f\u00e1rmacos en diferentes muestras biol\u00f3gicas. ii) la informaci\u00f3n resultante del an\u00e1lisis de las concentraciones de f\u00e1rmaco en distintas matrices biol\u00f3gicas y su posterior estudio farmacocin\u00e9tico\/farmacodin\u00e1mico es muy valiosa para la optimizaci\u00f3n terap\u00e9utica de un determinado f\u00e1rmaco y patolog\u00eda. objetivo: desarrollo, puesta a punto y validaci\u00f3n de 4 m\u00e9todos anal\u00edticos para la determinaci\u00f3n de linezolid y vancomicina en plasma y tejido pulmonar para su posterior implementaci\u00f3n en estudios de farmacocin\u00e9tica\/farmacodinamia. material y m\u00e9todos: dise\u00f1o y an\u00e1lisis de las condiciones cromatogr\u00e1ficas \u00f3ptimas para la cuantificaci\u00f3n de f\u00e1rmacos en diversas matrices biol\u00f3gicas. Posteriormente se realiza el estudio de los par\u00e1metros de calidad: exactitud, precisi\u00f3n, linealidad, l\u00edmite de detecci\u00f3n, l\u00edmite de cuantificaci\u00f3n, recuperaci\u00f3n, selectividad, especificidad y estabilidad seg\u00fan las normas de las principales agencias reguladoras (fda y emea). resultados: las 4 metodolog\u00edas dise\u00f1adas y validadas resultan adecuadas para analizar y cuantificar el linezolid y la vancomicina en plasma y en tejido pulmonar ya que los par\u00e1metros de calidad han cumplido las normas de aceptaci\u00f3n editadas por la fda y emea.  conclusiones: los 4 m\u00e9todos son exactos, precisos, lineales, sensibles, estables y todos ellos recuperan m\u00e1s del 90% del f\u00e1rmaco de la matriz original. Adem\u00e1s son r\u00e1pidos, sencillos y de bajo coste econ\u00f3mico. Las t\u00e9cnicas en tejido pulmonar ser\u00e1n una herramienta \u00fatil para desarrollar estudios farmacocin\u00e9ticos de penetraci\u00f3n de linezolid y vancomicina en dicha matriz.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n de f\u00e1rmacos en diferentes matrices biol\u00f3gicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n de f\u00e1rmacos en diferentes matrices biol\u00f3gicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Guerrero Molina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Helena Colom Codina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi To figueras <\/li>\n<li>Mar\u00eda Sarasa nacenta (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Guerrero Molina Introducci\u00f3n: la cromatograf\u00eda l\u00edquida de alta eficacia (hplc) es la t\u00e9cnica de referencia en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1595,951],"tags":[122660,116081,201274,75919],"class_list":["post-98409","post","type-post","status-publish","format-standard","hentry","category-analisis-cromatografico","category-barcelona","tag-helena-colom-codina","tag-jordi-to-figueras","tag-laura-guerrero-molina","tag-maria-sarasa-nacenta"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/98409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=98409"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/98409\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=98409"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=98409"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=98409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}