{"id":98437,"date":"2018-03-11T10:19:12","date_gmt":"2018-03-11T10:19:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-transcripcion-en-el-desarrollo-del-telencefalo-efectos-de-tbr1-y-gsx2-en-celulas-madre-y-progenitores-neurales\/"},"modified":"2018-03-11T10:19:12","modified_gmt":"2018-03-11T10:19:12","slug":"factores-de-transcripcion-en-el-desarrollo-del-telencefalo-efectos-de-tbr1-y-gsx2-en-celulas-madre-y-progenitores-neurales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-transcripcion-en-el-desarrollo-del-telencefalo-efectos-de-tbr1-y-gsx2-en-celulas-madre-y-progenitores-neurales\/","title":{"rendered":"Factores de transcripci\u00f3n en el desarrollo del telenc\u00e9falo: efectos de tbr1 y gsx2 en c\u00e9lulas madre y progenitores neurales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hector Ruben Mendez Gomez <\/strong><\/h2>\n<p>El papel de los factores de transcripci\u00f3n es muy relevante durante el desarrollo del sistema nervioso central. El estudio de la funci\u00f3n de estos factores en la biolog\u00eda de las c\u00e9lulas madre y progenitores neurales, la generaci\u00f3n de neuronas, su migraci\u00f3n y su diferenciaci\u00f3n, resultan claves para comprender la formaci\u00f3n del sistema nervioso, y para plantearse posibles terapias reparativas. el desarrollo del trabajo ha consistido fundamentalmente en el estudio de los factores de transcripci\u00f3n t-box brain 1(tbr1) y genetic screened homeobox (gsx2) en el desarrollo del sistema nervioso de rat\u00f3n. Para ello, mediante la t\u00e9cnica de sobreexpresi\u00f3n g\u00e9nica con vectores retrovirales, se han analizado los efectos de tbr1, gsx2 en la proliferaci\u00f3n, diferenciaci\u00f3n y migraci\u00f3n de c\u00e9lulas madre neurales y progenitores del bo. los resultado encontrados en esta tesis indican que tbr1 puede tener un papel m\u00e1s temprano en el desarrollo del bo al propuesto anteriormente. Se cre\u00eda implicado exclusivamente en maduraci\u00f3n neuronal, sin embargo, nuestros resultados proponen un efecto en la elecci\u00f3n de fenotipo neural, principalmente inhibiendo la generaci\u00f3n de astrocitos y aumentando la formaci\u00f3n de neuronas, al menos en cultivo celular. con respecto a gsx2, hemos encontrado un efecto importante sobre las c\u00e9lulas madre neurales. estas c\u00e9lulas, en presencia de gsx2 sufren alteraciones en la proliferaci\u00f3n, autorrenovaci\u00f3n y diferenciaci\u00f3n neurales, no encontrando un incremento en la neurog\u00e9nesis, como inicialmente se hab\u00eda especulado. nuestros resultados sugieren que la regulaci\u00f3n de los niveles de expresi\u00f3n de factores de transcripci\u00f3n es clave para el control del n\u00famero y la diferenciaci\u00f3n de c\u00e9lulas madre y progenitores neurales. Dicha regulaci\u00f3n puede ser empleada en protocolos de terapia celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores de transcripci\u00f3n en el desarrollo del telenc\u00e9falo: efectos de tbr1 y gsx2 en c\u00e9lulas madre y progenitores neurales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores de transcripci\u00f3n en el desarrollo del telenc\u00e9falo: efectos de tbr1 y gsx2 en c\u00e9lulas madre y progenitores neurales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hector Ruben Mendez Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Vicario Abejon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Cavada Martinez <\/li>\n<li>josep m. Canals coll (vocal)<\/li>\n<li>carme Gallego gonzalez (vocal)<\/li>\n<li>thomas Schimmang (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hector Ruben Mendez Gomez El papel de los factores de transcripci\u00f3n es muy relevante durante el desarrollo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[40436,33693,14535,201313,189678,65698],"class_list":["post-98437","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carlos-vicario-abejon","tag-carme-gallego-gonzalez","tag-carmen-cavada-Martinez","tag-hector-ruben-mendez-gomez","tag-josep-m-canals-coll","tag-thomas-schimmang"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/98437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=98437"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/98437\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=98437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=98437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=98437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}