{"id":98628,"date":"2018-03-11T10:19:30","date_gmt":"2018-03-11T10:19:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-metastasis-hepaticas-de-cancer-colorrectal-con-rescate-quirurgico-en-un-hospital-de-tercer-nivel-identificacion-de-marcadores-biologicos-pronosticos\/"},"modified":"2018-03-11T10:19:30","modified_gmt":"2018-03-11T10:19:30","slug":"estudio-de-las-metastasis-hepaticas-de-cancer-colorrectal-con-rescate-quirurgico-en-un-hospital-de-tercer-nivel-identificacion-de-marcadores-biologicos-pronosticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/estudio-de-las-metastasis-hepaticas-de-cancer-colorrectal-con-rescate-quirurgico-en-un-hospital-de-tercer-nivel-identificacion-de-marcadores-biologicos-pronosticos\/","title":{"rendered":"Estudio de las met\u00e1stasis hep\u00e1ticas de c\u00e1ncer colorrectal con rescate quir\u00fargico en un hospital de tercer nivel. identificaci\u00f3n de marcadores biol\u00f3gicos pron\u00f3sticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Manuel Borrego Estella <\/strong><\/h2>\n<p>Objetivos: determinar los factores preoperatorios, intraoperatorios y postoperatorios en una serie de 100 pacientes intervenidos por met\u00e1stasis hep\u00e1ticas de c\u00e1ncer colorrectal (mhccr).  material y m\u00e9todos: car\u00e1cter retrospectivo, datos de 100 pacientes consecutivos desde enero 2004 hasta agosto 2008 (seguimiento m\u00ednimo 1 a\u00f1o), sometidos a 127 resecciones hep\u00e1ticas (rh), por mhccr, realizado por un equipo multidisciplinar. Resultados: supervivencia actuarial tras la colectom\u00eda 1-3-5 a\u00f1os: 99-69-39%; supervivencia actuarial tras la hepatectom\u00eda 1-3-5 a\u00f1os: 92-48-30% y la supervivencia libre enfermedad tras la primera hepatectom\u00eda 1-3-5 a\u00f1os: 85-42-24%. El 27% con complicaciones postoperatorias grados i- ii de la clasificaci\u00f3n de clavien y dindo y el 13% complicaciones grados iii-iv. Tasa de mortalidad a 30 d\u00edas ha sido nula. La edad fue 64\u00c2\u00b110 (38-86) a\u00f1os y mayor\u00eda de varones (57%). Sincronicidad de las mh-ccr fue del 37%. Estancia media hospitalaria de 12\u00c2\u00b16 (5-37) d\u00edas. 92% tipo histol\u00f3gico convencional y con buen o nivel medio en cuanto al grado de diferenciaci\u00f3n tumoral, el 91%. Crecimiento infiltrante en 57% de pacientes (43% expansivo) y microsat\u00e9lites en 17% de pacientes. Conclusiones: entre los factores preoperatorios, irresecabilidad inicial de las mh, edad superior a 65 a\u00f1os, sincronicidad y un intervalo libre de enfermedad menor a 24 meses tras colectom\u00eda, han sido factores de mal pron\u00f3stico. Entre los factores intraoperatorios, la realizaci\u00f3n de una hepatectom\u00eda mayor, han sido factor de mal pron\u00f3stico. Entre los factores postoperatorios, rehepatectom\u00eda, recidiva extrahep\u00e1tica, intervalo libre de enfermedad menor a 24 meses tras la hepatectom\u00eda, margen resecci\u00f3n inferior a 10 mm., Microsatelitosis por encima de 5 mm. Y un grado de diferenciaci\u00f3n tumoral poco diferenciado\/indiferenciado, han sido factores de mal pron\u00f3stico. Por estudio microarrays de tejidos (tma), el an\u00e1lisis uni\/multivariante no encontr\u00f3 factores inmunohistoqu\u00edmicos asociados a recidiva o\/y mortalidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las met\u00e1stasis hep\u00e1ticas de c\u00e1ncer colorrectal con rescate quir\u00fargico en un hospital de tercer nivel. identificaci\u00f3n de marcadores biol\u00f3gicos pron\u00f3sticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las met\u00e1stasis hep\u00e1ticas de c\u00e1ncer colorrectal con rescate quir\u00fargico en un hospital de tercer nivel. identificaci\u00f3n de marcadores biol\u00f3gicos pron\u00f3sticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Manuel Borrego Estella <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Garcia Criado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Gomez alonso <\/li>\n<li>Jes\u00fas Esarte muniain (vocal)<\/li>\n<li>joaqu\u00edn Bernal jaulin (vocal)<\/li>\n<li>Andr\u00e9s Monz\u00f3n abad (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Manuel Borrego Estella Objetivos: determinar los factores preoperatorios, intraoperatorios y postoperatorios en una serie de 100 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