{"id":98664,"date":"2018-03-11T10:19:30","date_gmt":"2018-03-11T10:19:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-los-gliomas-identificacion-de-marcadores-diagnosticos-y-pronosticos\/"},"modified":"2018-03-11T10:19:30","modified_gmt":"2018-03-11T10:19:30","slug":"caracterizacion-molecular-de-los-gliomas-identificacion-de-marcadores-diagnosticos-y-pronosticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-los-gliomas-identificacion-de-marcadores-diagnosticos-y-pronosticos\/","title":{"rendered":"Caracterizaci\u00f3n molecular de los gliomas.identificaci\u00f3n de marcadores diagn\u00f3sticos y pron\u00f3sticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Ruano Dominguez <\/strong><\/h2>\n<p>El glioblastoma (gb) es el tumor cerebral m\u00e1s frecuente y maligno en adultos, debido a la capacidad que presenta para infiltrar e invadir tejido cerebral normal. A pesar del tratamiento con radioterapia y quimioterapia, la supervivencia media de los pacientes con gb es de alrededor de 1 a\u00f1o. el objetivo general planteado en esta tesis doctoral es el estudio de las alteraciones gen\u00e9tico-moleculares en gbs para la identificaci\u00f3n de genes candidatos con valor diagn\u00f3stico y pron\u00f3stico. Para ello se han utilizado t\u00e9cnicas de an\u00e1lisis a gran escala (microarrays de \u00e1cidos nucleicos y matrices de tejidos) que aumentan de manera significativa la resoluci\u00f3n y el n\u00famero de muestras que se pueden analizar en un solo experimento en comparaci\u00f3n con las t \u00e9cnicas de citogen\u00e9tica y gen\u00e9tica molecular cl\u00e1sicas.  a partir del an\u00e1lisis de las variaciones en la dosis g\u00e9nica y los perfiles de expresi\u00f3n de los genes en gbs se ha podido: &#8211; identificar un nuevo amplic\u00f3n en 4p15, as\u00ed como nuevos genes candidato s en los amplicones detectados en 4p15 (sla\/lp y stim2), 13q32-34 (tnfsf13b y col4a2) y 1q32 (mdm4 y pik3c2b) que podr\u00edan estar implicados en la patog\u00e9nesis de los gbs.  &#8211; describir una firma molecular compuesta por genes implicados en invasi\u00f3n, angi og\u00e9nesis, ciclo celular y apoptosis, entre los que se propone a la anexina 1 como marcador relacionado con el diagn\u00f3stico diferencial de astrocitomas, oligoastrocitomas y oligodendrogliomas. &#8211; identificar marcadores pron\u00f3sticos en gbs, tales como los  genes de la ruta pi3k\/akt, la alteraci\u00f3n simult\u00e1nea de egfr y p53, y la amplificaci\u00f3n de cdk4.  estos an\u00e1lisis nos han permitido profundizar en los mecanismos moleculares subyacentes en la patolog\u00eda de los gbs, con lo que hemos podido identificar ma rcadores diagn\u00f3sticos y factores pron\u00f3sticos de inter\u00e9s en estos tumores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n molecular de los gliomas.identificaci\u00f3n de marcadores diagn\u00f3sticos y pron\u00f3sticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n molecular de los gliomas.identificaci\u00f3n de marcadores diagn\u00f3sticos y pron\u00f3sticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Ruano Dominguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>B\u00e1rbara Melendez Asensio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Oya otero <\/li>\n<li>teresa Ribalta farres (vocal)<\/li>\n<li>Jes\u00fas Vaquero crespo (vocal)<\/li>\n<li>Javier Ben\u00edtez ortiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Ruano Dominguez El glioblastoma (gb) es el tumor cerebral m\u00e1s frecuente y maligno en adultos, debido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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