{"id":98704,"date":"2018-03-11T10:19:35","date_gmt":"2018-03-11T10:19:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-de-los-alergenos-principales-de-sanda%c2%ada\/"},"modified":"2018-03-11T10:19:35","modified_gmt":"2018-03-11T10:19:35","slug":"identificacion-y-caracterizacion-de-los-alergenos-principales-de-sanda%c2%ada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-de-los-alergenos-principales-de-sanda%c2%ada\/","title":{"rendered":"Identificaci\u00f3n y caracterizaci\u00f3n de los al\u00e9rgenos principales de sand\u00eda."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Barbara Cases Ortega <\/strong><\/h2>\n<p>La alergia a alimentos se engloba dentro de las reacciones de hipersensibilidad a alimentos en las que participa el sistema inmune. Son muchos los alimentos susceptibles de causar alergia, pero son relativamente pocos los que provocan la mayor\u00eda de l os casos y se pueden agrupar en: leche, huevo, frutos secos, frutas, pescado y marisco. centr\u00e1ndonos en la alergia a alimentos de origen vegetal,  se acepta que pueda ser el resultado de una primera sensibilizaci\u00f3n a p\u00f3lenes o l\u00e1tex que derivar\u00eda des pu\u00e9s a alergia alimentaria por reactividad cruzada, aunque no todos los casos de alergia alimentaria se deben a casos de reacci\u00f3n cruzada con prote\u00ednas de polen. A pesar de que la alergia a frutas es una causa muy frecuente de alergia alimentaria en adultos, que ha sido ampliamente estudiada, existen pocos estudios acerca de la alergia a los alimentos de origen vegetal pertenecientes a la familia de las cucurbit\u00e1ceas. el objetivo de este trabajo ha sido la identificaci\u00f3n de los al\u00e9rgenos de sand \u00eda, para lo cual se purificaron por t\u00e9cnicas de cromatograf\u00edas los tres al\u00e9rgenos principales de esta fruta, identific\u00e1ndose mediante espectrometr\u00eda de masas como profilina (14 kda), malato deshidrogenasa o mdh (36 kda) y triosa fosfato isomerasa o t pi (28 kda).  posteriormente se caracterizaron la profilina, por ser un panalergeno reconocido, y la mdh por ser el al\u00e9rgeno al que m\u00e1s pacientes estaban sensibilizados (96 ).  por primera vez se obtuvo la secuencia de  la profilina de sand\u00eda, a part ir de la cual se ha clonado y expresado esta prote\u00edna en pichia pastoris. La profilina recombinante producida result\u00f3 ser inmunol\u00f3gicamente equivalente a la natural, lo que la convierte en un posible sustituto de \u00e9sta para el diagn\u00f3stico de la sensib ilizaci\u00f3n a profilinas vegetales. Tras la clonaci\u00f3n y expresi\u00f3n de la mdh de sand\u00eda utilizando el sistema de los baculovirus, se observ\u00f3 que la forma recombinante no  era reconocida por las iges espec\u00edficas presentes en el suero de los pacientes, res ultando inadecuada como sustituto de la forma natural, tanto para fines diagn\u00f3sticos como de inmunoterapia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n y caracterizaci\u00f3n de los al\u00e9rgenos principales de sand\u00eda.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n y caracterizaci\u00f3n de los al\u00e9rgenos principales de sand\u00eda. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Barbara Cases Ortega <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Cuesta Herranz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>araceli D\u00edaz perales (vocal)<\/li>\n<li>Santiago Quirce gancedo (vocal)<\/li>\n<li>Emilio \u00e1lvarez cuesta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Barbara Cases Ortega La alergia a alimentos se engloba dentro de las reacciones de hipersensibilidad a alimentos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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