{"id":98775,"date":"2018-03-11T10:19:39","date_gmt":"2018-03-11T10:19:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reacciones-de-michael-organocatala%c2%adticas-promovidas-por-pirrolidinas-quirales\/"},"modified":"2018-03-11T10:19:39","modified_gmt":"2018-03-11T10:19:39","slug":"reacciones-de-michael-organocatala%c2%adticas-promovidas-por-pirrolidinas-quirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-las-reacciones-organicas\/reacciones-de-michael-organocatala%c2%adticas-promovidas-por-pirrolidinas-quirales\/","title":{"rendered":"Reacciones de michael organocatal\u00edticas promovidas por pirrolidinas quirales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Vera Salas <\/strong><\/h2>\n<p>La presente tesis ha tenido como objetivo contribuir en la reacci\u00f3n de michael organocatal\u00edtica v\u00eda enamina e i\u00f3n iminio, con nitrocompuestos y sulfonas tanto como aceptores como dadores, promovidas por aminas secundarias quirales. Mas concretamente se ha estudiado la reacci\u00f3n de aldeh\u00eddos enolizables a nitroalquenos y sulfonas \u00c2\u00bf,\u00edY-insaturadas as\u00ed como la adici\u00f3n conjugada de nitroalcanos y bis arilsulfonil metano a aldeh\u00eddos \u00c2\u00bf,\u00edY-insaturados. . con lo que se ha dise\u00f1ado un nuevo catalizador bifuncional que ha demostrado ser altamente eficiente en la adici\u00f3n de michael de aldeh\u00eddos a nitroalqunos que conduce a los correspondientes aductos de adici\u00f3n con un alto grado de diastereo-y enantiocontrol.  se ha dise\u00f1ando una nueva familia de catalizadores altamente eficaces para efectuar adiciones conjugadas de nucle\u00f3filos carbonados a enales v\u00eda i\u00f3n iminio compatibles con medios acuosos. se ha descrito una metodolog\u00eda catal\u00edtica para la s\u00edntesis de \u00c2\u00bf-lactonas, ceando tres centros estereog\u00e9nicos consecutivos de forma altamente estereoselectiva. Mediante dicha metodolog\u00eda se introduce un protocolo operacional simple a partir de vinil sulfonas f\u00e1cilmente asequibles y aldeh\u00eddos no modificados  como sustratos de partida.  y finalmente se ha desarrollado una ruta sint\u00e9tica organocatal\u00edtica para la \u00edY-alquilaci\u00f3n formal de enales con una utilizaci\u00f3n de una bis(sulfona) c\u00edclica. Esta se adiciona eficientemente a aldeh\u00eddos \u00c2\u00bf,\u00edY-insaturados mediante activaci\u00f3n v\u00eda i\u00f3n iminio, y tras una alquilaci\u00f3n-sulfonaci\u00f3n one-pot permite acceder a una gran diversidad de compuestos como son alcoholes, aldeh\u00eddos y acetales de forma altamente enenaitoselectiva.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reacciones de michael organocatal\u00edticas promovidas por pirrolidinas quirales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reacciones de michael organocatal\u00edticas promovidas por pirrolidinas quirales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Vera Salas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonia Mielgo Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Font cierco <\/li>\n<li>celia Andr\u00e9s Juan (vocal)<\/li>\n<li>Miguel \u00e1ngel Yus astiz (vocal)<\/li>\n<li>Jes\u00fas Garcia castillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Vera Salas La presente tesis ha tenido como objetivo contribuir en la reacci\u00f3n de michael organocatal\u00edtica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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