{"id":98791,"date":"2018-03-11T10:19:39","date_gmt":"2018-03-11T10:19:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-cardiotrofina-1-en-la-hipertrofia-ventricular-izquierda-del-paciente-hipertenso-estudios-geneticos-y-moleculares\/"},"modified":"2018-03-11T10:19:39","modified_gmt":"2018-03-11T10:19:39","slug":"papel-de-la-cardiotrofina-1-en-la-hipertrofia-ventricular-izquierda-del-paciente-hipertenso-estudios-geneticos-y-moleculares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/papel-de-la-cardiotrofina-1-en-la-hipertrofia-ventricular-izquierda-del-paciente-hipertenso-estudios-geneticos-y-moleculares\/","title":{"rendered":"Papel de la cardiotrofina-1 en la hipertrofia ventricular izquierda del paciente hipertenso: estudios gen\u00e9ticos y moleculares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Alejandro Robador Llorente <\/strong><\/h2>\n<p>Hypertensive heart disease (hhd) comprises the structural and functional alterations that the heart suffers as a response to the stress of increased blood pressure. The most characteristic clinical expression of hhd is left ventricular hypertrophy (lvh). Cardiotrophin-1 (ct-1) is a cytokine that is critically involved in the development of lvh, as clinical and experimental evidences indicate. We have searched for genetic variants of the human ct-1 gene (ctf1) and we have identified two polymorphisms, the 1742(c\/g) variant in the first intron and the 6662(c\/t) variant in the third exon. Our data indicate that the 1742(c\/g) polymorphism is associated with hypertension and with the prevalence of lvh. We have found that the 1742(c\/g) polymorphism is a significant determinant of the serum levels of ct-1 and also of the left ventricular mass index, after adjusting for confounding factors such as age, sex, systolic blood pressure and antihypertensive treatment. Collectively, our data suggest that the gg genotype for the 1742(c\/g) polymorphism may be a protective against lvh in essential hypertension. We also have carried out molecular studies in which we have found out that hypoxic stress increases the transcriptional activity of the human promoter of ct-1 gene, in hl-1 cardiomyocytes. These results are highly interesting due to the relevance of hypoxia in the context of hypertension and in the development of lvh. We have characterized that the main transcription factor involved in the regulation of human ct-1 promoter by hypoxia is hif-1. We determined that the mechanisms by which hif-1 regulates the human ct-1 promoter include the direct interaction between hif-1 and two functional hypoxia response elements of the promoter sequence.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la cardiotrofina-1 en la hipertrofia ventricular izquierda del paciente hipertenso: estudios gen\u00e9ticos y moleculares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la cardiotrofina-1 en la hipertrofia ventricular izquierda del paciente hipertenso: estudios gen\u00e9ticos y moleculares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Alejandro Robador Llorente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Zalba Go\u00f1i<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Redon mas <\/li>\n<li>Jos\u00e9 Mart\u00ednez gonz\u00e1lez (vocal)<\/li>\n<li>vicente Andr\u00e9s Garc\u00eda (vocal)<\/li>\n<li>\u00f3scar Mar\u00eda Beloqui ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Alejandro Robador Llorente Hypertensive heart disease (hhd) comprises the structural and functional alterations that the heart [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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