{"id":98858,"date":"2018-03-11T10:19:44","date_gmt":"2018-03-11T10:19:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/assessing-human-growth-hormone-variants-to-determine-their-potential-relevance-in-anti-doping-and-clinical-analysis\/"},"modified":"2018-03-11T10:19:44","modified_gmt":"2018-03-11T10:19:44","slug":"assessing-human-growth-hormone-variants-to-determine-their-potential-relevance-in-anti-doping-and-clinical-analysis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/assessing-human-growth-hormone-variants-to-determine-their-potential-relevance-in-anti-doping-and-clinical-analysis\/","title":{"rendered":"Assessing human growth hormone variants to determine their potential relevance in anti-doping and clinical analysis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gerard Such Sanmart\u00edn <\/strong><\/h2>\n<p>La hormona de crecimiento humana (gh) participa en el crecimiento post-longitudinal y en el metabolismo de l\u00edpidos y carbohidratos, y comprende un extraordinario n\u00famero de prote\u00ednas de secuencias similares, generadas tanto gen\u00e9ticamente como post-translacional, que en algunos casos muestran actividades biol\u00f3gicas claramente diferenciadas. Los m\u00e9todos actuales utilizados por su cuantificaci\u00f3n se basan principalmente en una immunodetecci\u00f3n espec\u00edfica de las variantes de gh m\u00e1s concentradas en circulaci\u00f3n sangu\u00ednea. Sin embargo, no queda claro cu\u00e1les variantes se reconocen en cada caso, ni cu\u00e1l es la concentraci\u00f3n real de algunas de estas variantes. Posiblemente relacionado, los inmunoensayos actualmente utilizados muestran una disparidad de resultados que dificultan la comparaci\u00f3n de datos de ensayos diferentes, con consecuencias directas en el campo cl\u00ednico. Dentro de un contexto de dopaje, la administraci\u00f3n ilegal de gh recombinando constituye un desaf\u00edo complejo, considerando el hecho de que la variante farmac\u00e9utica y la variante de gh nativa de 22 kda no muestran ninguna diferencia que permita una detecci\u00f3n directa. No obstante, la administraci\u00f3n del medicamento farmac\u00e9utico inhibe la producci\u00f3n natural de la hormona, derivando en cambios entre la concentraci\u00f3n relativa de algunas de estas variantes. En este caso, es de m\u00e1xima importancia cu\u00e1les variantes son detectadas, ya que eso constituye la base de este m\u00e9todo de antidopaje de gh.  aqu\u00ed, se estudia la relevancia de algunas variantes de gh, incluyendo su generaci\u00f3n, caracterizaci\u00f3n, an\u00e1lisis v\u00eda anticuerpos espec\u00edficos y su detecci\u00f3n en muestras biol\u00f3gicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Assessing human growth hormone variants to determine their potential relevance in anti-doping and clinical analysis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Assessing human growth hormone variants to determine their potential relevance in anti-doping and clinical analysis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gerard Such Sanmart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Segura<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: david Andreu mart\u00ednez <\/li>\n<li>moutian Wu (vocal)<\/li>\n<li>laura Lechuga gomez (vocal)<\/li>\n<li>Jos\u00e9 Barbosa torralbo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gerard Such Sanmart\u00edn La hormona de crecimiento humana (gh) participa en el crecimiento post-longitudinal y en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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