{"id":98903,"date":"2018-03-11T10:19:49","date_gmt":"2018-03-11T10:19:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/amidas-de-seudoefedrina-estereocontrol-en-adiciones-14-a-sistemas-policonjugados-y-en-reacciones-aldolicas-tipo-acetato-con-aldeha%c2%addos-quirales\/"},"modified":"2018-03-11T10:19:49","modified_gmt":"2018-03-11T10:19:49","slug":"amidas-de-seudoefedrina-estereocontrol-en-adiciones-14-a-sistemas-policonjugados-y-en-reacciones-aldolicas-tipo-acetato-con-aldeha%c2%addos-quirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-las-reacciones-organicas\/amidas-de-seudoefedrina-estereocontrol-en-adiciones-14-a-sistemas-policonjugados-y-en-reacciones-aldolicas-tipo-acetato-con-aldeha%c2%addos-quirales\/","title":{"rendered":"Amidas de seudoefedrina: estereocontrol en adiciones 1,4 a sistemas policonjugados y en reacciones ald\u00f3licas tipo acetato con aldeh\u00eddos quirales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Ocejo Lopez De Guere\u00f1a <\/strong><\/h2>\n<p>En el trabajo de investigaci\u00f3n se ha estudiado la aplicabilidad del aminoalcohol seudoefedrina como auxiliar quiral en diferentes transformaciones estereoselectivas unido bien al componente electr\u00f3filo o al nucle\u00f3filo de la reacci\u00f3n. En primer lugar se ha llevado a cabo un estudio de la regio- y estereoselectividad de la reacci\u00f3n de adici\u00f3n conjugada sobre amidas \u00c2\u00bf,\u00edY,\u00c2\u00bf,\u00c2\u00bf-insaturadas cuando este aminoalcohol es incorporado sobre el aceptor conjugado (electr\u00f3filo) comprob\u00e1ndose como dicho auxiliar ejerce una buena inducci\u00f3n 1,5 a pesar de la lejan\u00eda con respecto al centro de reacci\u00f3n. \t              en segundo lugar, se ha estudiado el empleo del auxiliar quiral unido al componente nucle\u00f3filo en reacciones ald\u00f3licas en condiciones de doble inducci\u00f3n asim\u00e9trica. De esta manera, la reacci\u00f3n entre una serie de \u00c2\u00bf-aminoaldeh\u00eddos quirales y los enolatos derivados de acetamidas de (r,r) y (s,s)-seudoefedrina permiten la obtenci\u00f3n de aductos \u00c2\u00bf-amino-\u00edY-hidroxicarbon\u00edlicos observ\u00e1ndose c\u00f3mo la combinaci\u00f3n matched de ambos reactivos contribuye a aumentar la diastereoselectividad del proceso.                mediante ambas metodolog\u00edas ha sido posible la obtenci\u00f3n de una serie de compuestos de gran inter\u00e9s posibilitando la recuperaci\u00f3n del auxiliar quiral en el proceso y demostrando su gran aplicabilidad. \u00e9sta tambi\u00e9n se hace del mismo modo patente en la s\u00edntesis de heterociclos nitrogenados como pirrolidinas, pirrolicidinas y derivados pirrolid\u00ednicos preparados mediante modificaciones sobre los productos obtenidos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Amidas de seudoefedrina: estereocontrol en adiciones 1,4 a sistemas policonjugados y en reacciones ald\u00f3licas tipo acetato con aldeh\u00eddos quirales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Amidas de seudoefedrina: estereocontrol en adiciones 1,4 a sistemas policonjugados y en reacciones ald\u00f3licas tipo acetato con aldeh\u00eddos quirales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Ocejo Lopez De Guere\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/01\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Luisa Carrillo Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Palacios gambra <\/li>\n<li>Jos\u00e9 Luis Mascare\u00f1as cid (vocal)<\/li>\n<li>tom\u00e1s Torroba p\u00e9rez (vocal)<\/li>\n<li>Mar\u00eda  del carmen Carre\u00f1o garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Ocejo Lopez De Guere\u00f1a En el trabajo de investigaci\u00f3n se ha estudiado la aplicabilidad del aminoalcohol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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