{"id":99134,"date":"2010-12-02T00:00:00","date_gmt":"2010-12-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reacciones-de-o-n-y-c-arilacion-catalizadas-por-cobre-en-medio-acuoso-una-va%c2%ada-de-acceso-a-heterociclos-de-interes\/"},"modified":"2010-12-02T00:00:00","modified_gmt":"2010-12-02T00:00:00","slug":"reacciones-de-o-n-y-c-arilacion-catalizadas-por-cobre-en-medio-acuoso-una-va%c2%ada-de-acceso-a-heterociclos-de-interes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-coordinados\/reacciones-de-o-n-y-c-arilacion-catalizadas-por-cobre-en-medio-acuoso-una-va%c2%ada-de-acceso-a-heterociclos-de-interes\/","title":{"rendered":"Reacciones de o-, n- y c-arilaci\u00f3n catalizadas por cobre en medio acuoso. una v\u00edade acceso a heterociclos de inter\u00e9s"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nekane Barbero Olmos <\/strong><\/h2>\n<p>Inicialmente se eval\u00faa el empleo de diferentes sistema catal\u00edticos de cobre, en la s\u00edntesis de benzo[d]oxazoles, benzo[d]imidazolonas y xantonas por medio de reacciones de o- y n-arilaci\u00f3n intramoleculares llevadas a cabo en agua. a continuaci\u00f3n se realiza la formaci\u00f3n  del enlace c(arilo)-o conducente al heterociclo de xantona no s\u00f3lo empleando la cat\u00e1lisis de cobre, sino tambi\u00e9n por medio de una reacci\u00f3n de sustituci\u00f3n nucle\u00f3fila arom\u00e1tica en agua. tambi\u00e9n se describe la s\u00edntesis divergente de las estructuras tetrac\u00edclicas de inter\u00e9s isoindolo[2,1-a]indol e indolo[1,2-a]indol, en tan s\u00f3lo dos y tres pasos de s\u00edntesis, respectivamente. Ambos heterociclos fusionados se preparan mediante el empleo de la cat\u00e1lisis de cobre: al primero de ellos se accede a trav\u00e9s de una reacci\u00f3n de c-arilaci\u00f3n directa y al segundo por medio de una reacci\u00f3n de n-arilaci\u00f3n, empleando precursores comunes. finalmente, se aborda la arilaci\u00f3n intramolecular directa de benzo(azoles) empleando un sistema catal\u00edtico compuesto por cobre, sin ligandos adicionales. Mediante la aplicaci\u00f3n de dicha estrategia se ha logrado no s\u00f3lo la c-arilaci\u00f3n de azaheterociclos poco comunes en este tipo de procesos, sino tambi\u00e9n preparar una serie de polic\u00edclos de interesantes propiedades farmacol\u00f3gicas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reacciones de o-, n- y c-arilaci\u00f3n catalizadas por cobre en medio acuoso. una v\u00edade acceso a heterociclos de inter\u00e9s<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reacciones de o-, n- y c-arilaci\u00f3n catalizadas por cobre en medio acuoso. una v\u00edade acceso a heterociclos de inter\u00e9s <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nekane Barbero Olmos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raul San Martin Faces<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Martin lomas <\/li>\n<li>eduardo Martinez de marigorta izaga (vocal)<\/li>\n<li>celia Andr\u00e9s Juan (vocal)<\/li>\n<li>julio \u00e1lvarez-builla g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nekane Barbero Olmos Inicialmente se eval\u00faa el empleo de diferentes sistema catal\u00edticos de cobre, en la s\u00edntesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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