{"id":99206,"date":"2018-03-11T10:20:13","date_gmt":"2018-03-11T10:20:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-evolucion-genetica-y-de-la-compartimentalizacion-del-virus-de-la-hepatitis-c-relacion-con-la-recidiva-de-la-infeccion-tras-el-trasplante-hepatico\/"},"modified":"2018-03-11T10:20:13","modified_gmt":"2018-03-11T10:20:13","slug":"estudio-de-la-evolucion-genetica-y-de-la-compartimentalizacion-del-virus-de-la-hepatitis-c-relacion-con-la-recidiva-de-la-infeccion-tras-el-trasplante-hepatico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-evolucion-genetica-y-de-la-compartimentalizacion-del-virus-de-la-hepatitis-c-relacion-con-la-recidiva-de-la-infeccion-tras-el-trasplante-hepatico\/","title":{"rendered":"Estudio de la evoluci\u00f3n gen\u00e9tica y de la compartimentalizaci\u00f3n del virus de la hepatitis c: relaci\u00f3n con la recidiva de la infecci\u00f3n tras el trasplante hep\u00e1tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Santseharay Ram\u00edrez Almeida <\/strong><\/h2>\n<p>La infecci\u00f3n causada por el virus de la hepatitis c (vhc) afecta 180 millones de personas en todo el mundo y es la primera causa de trasplante hep\u00e1tico (th). Tras el trasplante la infecci\u00f3n del injerto es universal. En algunos pacientes la recurrencia de la hepatitis tiene un curso leve, mientras que en otros se presenta de forma severa. Se desconocen los factores virol\u00f3gicos que influyen en la severidad de la recurrencia de la hepatitis post th. en un pocentaje significativo de pacientes con viremia muy baja o incluso negativa en el momento del th tambi\u00e9n se produce la infecci\u00f3n del injerto. En estos pacientes la contribuci\u00f3n de compartimentos extrahep\u00e1ticos a la infecci\u00f3n del injerto podria ser relevante.   -el estudio de la evoluci\u00f3n gen\u00e9tica de los genes ns3 y ns5b tras el th revel\u00f3 que existe una relaci\u00f3n entre mayor diversificaci\u00f3n del gen ns5b y recurrencia leve de la hepatitis post th, especialmente al a\u00f1o post th. Sin embargo, la evoluci\u00f3n gen\u00e9tica de ns3 no se relaciona con la gravedad de la recurrencia. -el estudio de la compartimentalizaci\u00f3n del vhc en pacientes sometidos a th revel\u00f3 que aproximadamente la mitad de estos pacientes presentan diferencias en la secuencia de la regi\u00f3n hvr-1 del virus aislado en suero, h\u00edgado, celulas mononucleares de sangre perif\u00e9rica y ganglio perihep\u00e1tico. -la presencia de arn del vhc en el explante, en el momento del th se relaciona con la recurrencia de la hepatitis post th en pacientes que habian respondido a l tratamiento antiviral mientras se encontraban en lista de espera para th. -el an\u00e1lisis de las secuencias post th revel\u00f3 que la fuente principal de viriones que producen la recurrencia de la infecci\u00f3n es el explante y que los virus presentes en compartimentos extrahep\u00e1ticos no juegan un papel relevante.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la evoluci\u00f3n gen\u00e9tica y de la compartimentalizaci\u00f3n del virus de la hepatitis c: relaci\u00f3n con la recidiva de la infecci\u00f3n tras el trasplante hep\u00e1tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la evoluci\u00f3n gen\u00e9tica y de la compartimentalizaci\u00f3n del virus de la hepatitis c: relaci\u00f3n con la recidiva de la infecci\u00f3n tras el trasplante hep\u00e1tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Santseharay Ram\u00edrez Almeida <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Forns Bernhardt<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosina Girones llop <\/li>\n<li>josep Quer sivila (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santseharay Ram\u00edrez Almeida La infecci\u00f3n causada por el virus de la hepatitis c (vhc) afecta 180 millones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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