{"id":99282,"date":"2018-03-11T10:20:22","date_gmt":"2018-03-11T10:20:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportaciones-de-la-bulbectoma%c2%ada-olfatoria-bilateral-en-la-rata-a-la-neurobiologa%c2%ada-y-tratamiento-de-la-depresion\/"},"modified":"2018-03-11T10:20:22","modified_gmt":"2018-03-11T10:20:22","slug":"aportaciones-de-la-bulbectoma%c2%ada-olfatoria-bilateral-en-la-rata-a-la-neurobiologa%c2%ada-y-tratamiento-de-la-depresion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurociencias\/aportaciones-de-la-bulbectoma%c2%ada-olfatoria-bilateral-en-la-rata-a-la-neurobiologa%c2%ada-y-tratamiento-de-la-depresion\/","title":{"rendered":"Aportaciones de la bulbectom\u00edaolfatoria bilateral en la rata a la neurobiolog\u00eda y tratamiento de la depresi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Rodriguez Gaztelumendi <\/strong><\/h2>\n<p>El objetivo general de la tesis ha sido el estudio de los cambios adaptativos en los sistemas de neurotransmisi\u00f3n seroton\u00e9rgico y endocannabinoide, en la expresi\u00f3n de diversos marcadores de neuroplasticidad y en la neurog\u00e9nesis hipocampal en el modelo de depresi\u00f3n de bulbectom\u00eda olfatoria bilateral en la rata as\u00ed como el efecto del tratamiento cr\u00f3nico con el antidepresivo fluoxetina. Los objetivos concretos del trabajo podr\u00edan dividirse en:  1. Evaluar las alteraciones conductuales inducidas por la bulbectom\u00eda olfatoriaa y el efecto que la administraci\u00f3n cr\u00f3nica de fluoxetina ejerce sobre dichas manifestaiones conductuales.  2. Analizar, mediante t\u00e9cnicas radiom\u00e9tricas, los posibles cambios adaptativos en la densidad y la funcionalidad del transportador de serotonina y de los receptores 5-ht1a, 5-ht1b y 5-ht2a tras la bulbectom\u00eda olfatoria y el tratamiento cr\u00f3nico con el antidepresivo fluoxetina.  3. Analizar, mediante t\u00e9cnicas radiom\u00e9tricas, los posibles cambios adaptativos en la densidad y la funcionalidad del receptor cannabinoide cb1 tras la bulbectom\u00eda olfatoria y el tratamiento cr\u00f3nico con fluoxetina.  4. Estudiar los posibles cambios en la expresi\u00f3n de los siguientes marcadores moleculares de neuroplasticidad tras la bulbectom\u00eda olfatoria y el tratamiento cr\u00f3nico con fluoxetina: factor bdnf y su receptor trkb mediante t\u00e9cnicas de hibridaci\u00f3n in situ y diversas prote\u00ednas intracelulares como erk\/perk, creb\/pcreb, akt y beta catenina utilizando t\u00e9cnicas de inmunodetecci\u00f3n por western-blot.  5. Valorar la existencia de modificaciones en la neurog\u00e9nesis hipocampal a consecuencia de la bulbectom\u00eda olfatoria y su posible modulaci\u00f3n por el tratamiento cr\u00f3nico con fluoxetina mediante t\u00e9cnicas inmunohistoqu\u00edmicas y de inmunoflurorescencia.  6. Establecer las posibles correlaciones entre los cabmios conductuales, neuroqu\u00edmicos, moleculares y celulares inducidos por la bulbectom\u00eda olfatoria y el tratamiento cr\u00f3nico con el antidepresivo fluoxetina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportaciones de la bulbectom\u00edaolfatoria bilateral en la rata a la neurobiolog\u00eda y tratamiento de la depresi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportaciones de la bulbectom\u00edaolfatoria bilateral en la rata a la neurobiolog\u00eda y tratamiento de la depresi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Rodriguez Gaztelumendi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Pazos Carro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arsenio Fern\u00e1ndez l\u00f3pez <\/li>\n<li>Jos\u00e9 Javier Meana Martinez (vocal)<\/li>\n<li>albert Adell calduch (vocal)<\/li>\n<li>Mar\u00eda  amor Hurle  gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Rodriguez Gaztelumendi El objetivo general de la tesis ha sido el estudio de los cambios adaptativos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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