{"id":99346,"date":"2018-03-11T10:20:27","date_gmt":"2018-03-11T10:20:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-sdf-1-en-el-timo-humano\/"},"modified":"2018-03-11T10:20:27","modified_gmt":"2018-03-11T10:20:27","slug":"papel-de-sdf-1-en-el-timo-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-sdf-1-en-el-timo-humano\/","title":{"rendered":"Papel de  sdf-1 en el timo humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Hernandez Lopez <\/strong><\/h2>\n<p>Sdf-1\/cxcl12 es una quimioquina constitutivamente expresada en numerosos \u00f3rganos e inicialmente caracterizada como factor de crecimiento de linfocitos b, demostr\u00e1ndose posteriormente su actividad quimiot\u00e1ctica para distintos tipos celulares. En el ti mo humano sdf-1 se une y se\u00f1aliza a trav\u00e9s de cxcr4, un receptor con siete dominios transmembrana acoplado a prote\u00ednas g, que tambi\u00e9n act\u00faa como correceptor para la infecci\u00f3n del vih. Los trabajos para determinar el papel de sdf-1 en timopoyesis han estado centrados principalmente en el modelo del rat\u00f3n, y la mayor\u00eda de ellos se han restringido a estudiar su papel en la migraci\u00f3n de los timocitos en diferenciaci\u00f3n, y su posicionamiento en los nichos adecuados donde reciben las se\u00f1ales de supervi vencia, proliferaci\u00f3n y\/o diferenciaci\u00f3n. En este trabajo analizamos el papel de la se\u00f1alizaci\u00f3n sdf-1 \/cxcr4 en la diferenciaci\u00f3n de los precursores t\u00edmicos humanos, as\u00ed como en uno de los componentes estrom\u00e1ticos esenciales en dicha diferenciaci\u00f3n,  las c\u00e9lulas dendr\u00edticas. Nuestros resultados indican que sdf-1 es producido en el timo humano por c\u00e9lulas epiteliales medulares y subcapsulares y cxcr4 es expresado mayoritariamente por los precursores t\u00edmicos cd34  comprometidos con el linaje t, re duci\u00e9ndose progresivamente su expresi\u00f3n en los siguientes estadios de diferenciaci\u00f3n. Funcionalmente, sdf-1 no participa de forma directa en la colonizaci\u00f3n del par\u00e9nquima t\u00edmico por los precursores linfo-hematopoy\u00e9ticos, pero es capaz de promover la  supervivencia y proliferaci\u00f3n de los precursores intrat\u00edmicos cd34 , actuando de forma sin\u00e9rgica con il-7. Al mismo tiempo, sdf-1 interviene en el mantenimiento de los timocitos dp (cd4 cd8 ) m\u00e1s inmaduros, aumentando su viabilidad. Por tanto, sdf-1  estar\u00eda implicado en el mantenimiento de la homeostasis t\u00edmica ejerciendo sus efectos sobre distintas poblaciones de timocitos. El efecto de sdf-1 en supervivencia no s\u00f3lo afecta a las poblaciones de timocitos inmaduros sino que adem\u00e1s ejerce una ac ci\u00f3n autocrina sobre las c\u00e9lulas dendr\u00edticas, incrementando la funcionalidad de las mismas. Globalmente, nuestros resultados ponen de manifiesto un importante papel de sdf-1 en la diferenciaci\u00f3n t humana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de  sdf-1 en el timo humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de  sdf-1 en el timo humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Hernandez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Varas Fajardo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>Manuel Ramirez orellan (vocal)<\/li>\n<li>rosa m. Y\u00e1\u00f1ez gonz\u00e1lez (vocal)<\/li>\n<li>silvia S\u00e1nchez ram\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Hernandez Lopez Sdf-1\/cxcl12 es una quimioquina constitutivamente expresada en numerosos \u00f3rganos e inicialmente caracterizada como factor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[6521,202784,194834,137175,67625,38642],"class_list":["post-99346","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-agustin-gregorio-zapata-gonzalez","tag-alberto-varas-fajardo","tag-carmen-hernandez-lopez","tag-manuel-ramirez-orellan","tag-rosa-m-yanez-gonzalez","tag-silvia-sanchez-ramon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/99346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=99346"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/99346\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=99346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=99346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=99346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}