{"id":99400,"date":"2018-03-11T10:20:27","date_gmt":"2018-03-11T10:20:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/snd1-garraiatzaile-hepatobiliarrak-eta-sepsia\/"},"modified":"2018-03-11T10:20:27","modified_gmt":"2018-03-11T10:20:27","slug":"snd1-garraiatzaile-hepatobiliarrak-eta-sepsia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-animal\/snd1-garraiatzaile-hepatobiliarrak-eta-sepsia\/","title":{"rendered":"Snd1, garraiatzaile hepatobiliarrak eta sepsia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yuri Rueda Estevez <\/strong><\/h2>\n<p>Snd1 proteina espezie askotan kontserbaturiko proteina da, eta betetzen dituen funtzioak anitzak. Lan gehienetan adierazpen genikoaren erregulazioarekin, mrna-ren edizioarekin eta irna-rekin erlazionatu izan da. Beste lan batzuetan aldiz, gure ikerkuntza-taldekoak barne, lipidoen metabolismoarekin ere zerikusia duela behatu da. Gure behaketen arabera, arratoien hepatozito primarioek jariatutako lipoproteinen konposaketa aldatu egiten da snd1-en adierazpen-mailaren arabera, eta bestalde esteatosia bultzatzen duten baldintza ezberdinen pean, snd1 zitosoletik gorputz lipidikoetara translokatzen da.   lan honetan snd1-en eta behazunaren fisiolog\u00edaren arteko erlazioa aztertu da. Kolestasia behazunaren fisiolog\u00edaren akatsa da, horren fluxua mozten denean gertatzen dena; askotan inflamazioak (sepsiak) eragiten du. Snd1-ekin duten erlazioa aztertu da.   lehenengo atal batean arratoien hepatozito primarioak erabili ditugu fenotipo kolestatikoa dutelako. Hauetan snd1-en adierazpen diferentziala eragin dugu bektore adenobiralekin. Gure emaitzetan ez da snd1-en adierazpenaren eraginik ikusi fenotipoaren gain.   bigarren atalean inflamazioa eta kolestasia eragin da saguetan, lipopolisakaridoaren (lps) administratuz. Honek snd1-en mrna-mailen igoera eragiten du, baina ez proteina-mailarena. Saguen hepatozito primarioak zitokina proinflamatorioekin tratatuta ez da snd1-en adierazpen-mailetan aldaketarik behatu, baina tnf\u00c2\u00bf-k frakzio azpizelular batzuetan dagoen p100-maila aldarazten du. Eragina ezberdina da sexuaren arabera. Emeetan behatutakoak iradokitzen du proteasomak snd1-en mailak kontrolatzen dituela, eta nf-\u00c2\u00bfb-bidez tnf\u00c2\u00bf-k snd1-en kokapena aldarazi dezakeela.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Snd1, garraiatzaile hepatobiliarrak eta sepsia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Snd1, garraiatzaile hepatobiliarrak eta sepsia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yuri Rueda Estevez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Patricia Aspichueta Celaa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jon Irazusta astiazaran <\/li>\n<li>susana Cristobal barragan (vocal)<\/li>\n<li>Rafael Aldabe arregui (vocal)<\/li>\n<li>Elena Bravo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yuri Rueda Estevez Snd1 proteina espezie askotan kontserbaturiko proteina da, eta betetzen dituen funtzioak anitzak. Lan gehienetan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9399,675,964,12909,3178],"tags":[202881,72633,71782,126002,149692,202880],"class_list":["post-99400","post","type-post","status-publish","format-standard","hentry","category-cultivo-celular","category-fisiologia-animal","category-lipidos","category-pais-vasco-euskal-herriko-unibertsitatea","category-proteinas","tag-elena-bravo","tag-jon-irazusta-astiazaran","tag-patricia-aspichueta-celaa","tag-rafael-aldabe-arregui","tag-susana-cristobal-barragan","tag-yuri-rueda-estevez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/99400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=99400"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/99400\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=99400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=99400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=99400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}