{"id":99430,"date":"2018-03-11T10:20:34","date_gmt":"2018-03-11T10:20:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/in-silico-analysis-of-regulatory-motifs-in-gene-promoters\/"},"modified":"2018-03-11T10:20:34","modified_gmt":"2018-03-11T10:20:34","slug":"in-silico-analysis-of-regulatory-motifs-in-gene-promoters","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/informatica\/in-silico-analysis-of-regulatory-motifs-in-gene-promoters\/","title":{"rendered":"In silico analysis of regulatory motifs in gene promoters"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nicol\u00e1s Bellora Pereyra <\/strong><\/h2>\n<p>La regulaci\u00f3n de la transcripci\u00f3n de los genes eucariotas es un proceso complejo que implica muchas prote\u00ednas diferentes, algunas de las cuales se unen a motivos de adn espec\u00edficos que se encuentran localizados en la regi\u00f3n promotora de los genes. Se espera que la necesidad de mantener las interacciones espec\u00edficas entre los factores de transcripci\u00f3n y las prote\u00ednas implicadas en el complejo de la arn polimerasa ii imponga limitaciones en la posici\u00f3n relativa y el espaciado de los motivos de interacci\u00f3n con el adn. El trabajo presentado en esta tesis incluye el desarrollo de un nuevo m\u00e9todo para la identificaci\u00f3n de motivos que presentan una localizaci\u00f3n preferencial en secuencias de adn y la implementaci\u00f3n de una aplicaci\u00f3n web p\u00fablica llamada peaks. Hemos investigado si la posici\u00f3n y la naturaleza de la mayor\u00eda de los motivos comunes depende del rango de expresi\u00f3n del gen. Hemos encontrado diferencias que sirven para ilustrar el hecho que muchas se\u00f1ales clave de regulaci\u00f3n g\u00e9nica pueden estar presentes en la regi\u00f3n proximal del promotor de los genes de mam\u00edferos. Tambi\u00e9n aplicamos otros m\u00e9todos para la identificaci\u00f3n de factores de transcripci\u00f3n (tfs) espec\u00edficos involucrados en la co-regulaci\u00f3n de un grupo de genes. Evidencia experimental de sitios de uni\u00f3n de factores de transcripci\u00f3n (tfbs) apoyan la relevancia biol\u00f3gica de nuestros resultados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>In silico analysis of regulatory motifs in gene promoters<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 In silico analysis of regulatory motifs in gene promoters <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nicol\u00e1s Bellora Pereyra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Del Mar Alba Soler<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: roderic Guig\u00f3 serra <\/li>\n<li>david Torrents arenales (vocal)<\/li>\n<li>Javierde las Rivas sanz (vocal)<\/li>\n<li>Emilio Salo boix (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nicol\u00e1s Bellora Pereyra La regulaci\u00f3n de la transcripci\u00f3n de los genes eucariotas es un proceso complejo que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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