{"id":99452,"date":"2018-03-11T10:20:34","date_gmt":"2018-03-11T10:20:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/avances-en-los-mecanismos-fisiopatologicos-del-sindrome-de-tourette\/"},"modified":"2018-03-11T10:20:34","modified_gmt":"2018-03-11T10:20:34","slug":"avances-en-los-mecanismos-fisiopatologicos-del-sindrome-de-tourette","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurologia\/avances-en-los-mecanismos-fisiopatologicos-del-sindrome-de-tourette\/","title":{"rendered":"Avances en los mecanismos fisiopatologicos del sindrome de tourette"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guadalupe Davila <\/strong><\/h2>\n<p>La revisi\u00f3n de la literatura y la experiencia cl\u00ednica de las dos ultimas d\u00e9cadas indica que hay aspectos del s\u00edndrome de tourette que a\u00fan no han sido explorados exhaustivamente, algunos de crucial importancia, ya sea, por su relevancia cl\u00ednica o porque pueden mejorar el conocimiento de los mecanismos fisiopatol\u00f3gicos de este s\u00edndrome. Por todo ello, y en base a la poblaci\u00f3n recibida en cl\u00ednica especializada se describen: (a) las anomal\u00edas encontradas a nivel del tronco cerebral en pacientes con s\u00edndrome de tourette; (b) los trastornos adquiridos por disfunci\u00f3n de los ganglios basales que remedan al s\u00edndrome de tourette (tourettismo); (c) aspectos concretos de comorbilidad en relaci\u00f3n al s\u00edndrome de asperger y suicidio: (1) nuestros hallazgos con resonancia magn\u00e9tica nuclear sugieren que la sustancia nigra est\u00e1 afectada en un subgrupo de pacientes con s\u00edndrome de tourette y que esta afectaci\u00f3n se asocia a un fenotipo diferente que incluye un mayor n\u00famero de estereotipias, presumiblemente por la interrupci\u00f3n de las conexiones con los circuitos motores, l\u00edmbicos y asociativos; (2) las lesiones focales de los circuitos prefronto-subcorticales pueden ocasionar tourettismo y reactivaci\u00f3n tard\u00eda de s\u00edntomas obsesivo-compulsivos, probablemente por la desinhibici\u00f3n de las proyecciones talamocorticales facilitada por la existencia de circuitos neurales especialmente vulnerables a desequilibrio entre las v\u00edas directa e indirecta de los ganglios basales; (3) los pacientes con s\u00edndrome de tourette y asperger co-m\u00f3rbidos que presentan un estilo de interacci\u00f3n social \u00abpasivo\u00bb son incapaces de detectar se\u00f1ales sociales complejas amenazantes que gu\u00eden su comportamiento y de reaccionar de forma apropiada en situaciones de peligro. Estos d\u00e9ficits se asocian a alteraci\u00f3n de funciones ejecutivas, atenci\u00f3n visual, reconocimiento de expresiones faciales y lenguaje emocional, percepci\u00f3n del dolor y cognici\u00f3n socio-afectiva; (4) los adolescentes y adultos j\u00f3venes con s\u00edndrome de tourette, comorbilidad psiqui\u00e1trica grave, especialmente depresi\u00f3n y conductas impulsivas-agresivas, pobre ajuste psicosocial y escasa respuesta al tratamiento deben ser supervisados regularmente por el personal socio-sanitario para detectar la existencia de ideaci\u00f3n suicida y eventos vitales negativos que podr\u00edan eventualmente conducir al suicidio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Avances en los mecanismos fisiopatologicos del sindrome de tourette<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Avances en los mecanismos fisiopatologicos del sindrome de tourette <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guadalupe Davila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/02\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcelo Luis Berthier Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 pablo Lara mu\u00f1oz <\/li>\n<li>carmen Garc\u00eda s\u00e1nchez (vocal)<\/li>\n<li>Jaime Kulisevsky bojarski (vocal)<\/li>\n<li>cristobal Carnero pardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guadalupe Davila La revisi\u00f3n de la literatura y la experiencia cl\u00ednica de las dos ultimas d\u00e9cadas indica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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