{"id":99501,"date":"2010-03-03T00:00:00","date_gmt":"2010-03-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinantes-celulares-plasmaticos-y-geneticos-de-riesgo-de-trombosis-y-hemorragia-en-pacientes-con-neoplasias-mieloproliferativas-cronicas-filadelfia-negativo\/"},"modified":"2010-03-03T00:00:00","modified_gmt":"2010-03-03T00:00:00","slug":"determinantes-celulares-plasmaticos-y-geneticos-de-riesgo-de-trombosis-y-hemorragia-en-pacientes-con-neoplasias-mieloproliferativas-cronicas-filadelfia-negativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/determinantes-celulares-plasmaticos-y-geneticos-de-riesgo-de-trombosis-y-hemorragia-en-pacientes-con-neoplasias-mieloproliferativas-cronicas-filadelfia-negativo\/","title":{"rendered":"Determinantes celulares, plasm\u00e1ticos y gen\u00e9ticos de riesgo de trombosis y hemorragia en pacientes con neoplasias mieloproliferativas cr\u00f3nicas filadelfia negativo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jose Moreno Belmonte <\/strong><\/h2>\n<p>Las neoplasias mieloproliferativas cr\u00f3nicas (nmpc) filadelfia negativo [(ph(-)] cl\u00e1sicas comprenden la trombocitemia esencial (te), la policitemia vera (pv) y la mielofibrosis primaria (mfp) y se caracterizan por la expansi\u00f3n clonal de la c\u00e9lula madre pluripotente, produciendo como resultado una hipercelularidad medular de predominio de una l\u00ednea espec\u00edfica; la trombosis y el sangrado son parte de la historia natural de este grupo de enfermedades, constituyendo sus principales causas de morbimortalidad. Trabajos recientes han sugerido un papel del componente celular (hemat\u00edes, plaquetas y leucocitos), de marcadores gen\u00e9ticos y de prote\u00ednas anticoagulantes en la patogenia de la trombosis en pacientes con te o pv, pero muchos de ellos no han sido validados y as\u00ed los datos son escasos y contradictorios. Los estudios de estas variables en la patolog\u00eda hemorr\u00e1gica es a\u00fan m\u00e1s limitada. Nuestra hip\u00f3tesis era que se podr\u00edan buscar y definir biomarcadores de riesgo de trombosis y de hemorragia, tanto a nivel celular, plasm\u00e1tico, como gen\u00e9tico, que ayudaran a trazar el perfil individual de riesgo de estas complicaciones hemost\u00e1ticas. Estudiamos en primer lugar, los polimorfismos hemost\u00e1ticos factor v leiden, pt g20210a, zpi r67stop, hpa-1b, hpa-2b, gpia c807t, psgl-1 vntr, fvii -323 del\/ins y tubb1 q43p, as\u00ed como el genotipo abo de nuestros pacientes, sin observar una asociaci\u00f3n entre \u00e9stos y la mayor incidencia de fen\u00f3menos trombohemorr\u00e1gicos. Estudiamos tambi\u00e9n la presencia de la mutaci\u00f3n jak2 v617f (descri<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinantes celulares, plasm\u00e1ticos y gen\u00e9ticos de riesgo de trombosis y hemorragia en pacientes con neoplasias mieloproliferativas cr\u00f3nicas filadelfia negativo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinantes celulares, plasm\u00e1ticos y gen\u00e9ticos de riesgo de trombosis y hemorragia en pacientes con neoplasias mieloproliferativas cr\u00f3nicas filadelfia negativo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jose Moreno Belmonte <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luisa Lozano Almela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Hern\u00e1ndez nieto <\/li>\n<li>carmen Burgaleta alonso de ozalla (vocal)<\/li>\n<li>vicente Vicente garcia (vocal)<\/li>\n<li>carles Besses raebel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jose Moreno Belmonte Las neoplasias mieloproliferativas cr\u00f3nicas (nmpc) filadelfia negativo [(ph(-)] cl\u00e1sicas comprenden la trombocitemia esencial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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