{"id":99542,"date":"2010-05-03T00:00:00","date_gmt":"2010-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-diada-cd40-cd40l-y-su-modulacion-por-la-adiponectina-en-el-sa%c2%adndrome-metabolico\/"},"modified":"2010-05-03T00:00:00","modified_gmt":"2010-05-03T00:00:00","slug":"estudio-de-la-diada-cd40-cd40l-y-su-modulacion-por-la-adiponectina-en-el-sa%c2%adndrome-metabolico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-clinica\/estudio-de-la-diada-cd40-cd40l-y-su-modulacion-por-la-adiponectina-en-el-sa%c2%adndrome-metabolico\/","title":{"rendered":"Estudio de la diada cd40\/cd40l y su modulaci\u00f3n por la adiponectina en el s\u00edndrome metab\u00f3lico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Restituto Arangu\u00edbel <\/strong><\/h2>\n<p>En el contexto del concepto actual del s\u00edndrome metab\u00f3lico como una enfermedad inflamatoria y protromb\u00f3tica, el presente estudio muestra que la v\u00eda del cd40\/cd40l puede desempe\u00f1ar un papel en el mayor riesgo cardiovascular de estos pacientes. Hemos encontrado concentraciones elevadas de la forma soluble del ligando de cd40 en pacientes con s\u00edndrome metab\u00f3lico, posiblemente procedente de las plaquetas. Estos niveles, se ha demostrado ampliamente en la bibliograf\u00eda disponible que se asocian con un aumento del riesgo cardiovascular. Otro hallazgo de este estudio es el incremento en la liberaci\u00f3n paquetar de scd40l en pacientes con s\u00edndrome metab\u00f3lico, lo que podr\u00eda ser responsable de la elevaci\u00f3n de la concentraci\u00f3n observada en el plasma. Adem\u00e1s de la forma soluble, en nuestros pacientes observamos un aumento de la expresi\u00f3n en los monocitos circulantes. Esta forma celular, puede directamente como ya se ha publicado, activar y desencadenar procesos proaterog\u00e9nicos en otros monocitos y en c\u00e9lulas endoteliales. Asimismo, el aumento de la expresi\u00f3n del receptor cd40 en monocitos de pacientes, indica que estos son m\u00e1s \u00c2\u00bfsusceptibles\u00c2\u00bf de ser activados por su ligando, lo cual, podr\u00eda contribuir a amplificar la respuesta inflamatoria y da\u00f1o vascular de los pacientes con s\u00edndrome metab\u00f3lico. en estos pacientes tambi\u00e9n se ha encontrado aumentada la agregaci\u00f3n plaquetar con respecto a los controles, asociada a niveles disminuidos de adiponectina. Tambi\u00e9n se muestra que la adiponectina regula el sistema cd40\/cd40l en monocitos, c\u00e9lulas endoteliales y plaquetas. Esta adipoquina disminuye la expresi\u00f3n de cd40\/cd40l en monocitos y c\u00e9lulas endoteliales. Y en las plaquetas, principal fuente de scd40l, la adiponectina disminuye la agregaci\u00f3n y la liberaci\u00f3n plaquetar de cd40l y p-selectina. Estos hallazgos suponen nuevos efectos antiinflamatorios y antitromb\u00f3ticos de la adiponectina y sugieren que la hipoadinectinemia podr\u00eda contribuir en parte a la inflamaci\u00f3n y estado protromb\u00f3tico que se encuentran en el s\u00edndrome metab\u00f3lico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la diada cd40\/cd40l y su modulaci\u00f3n por la adiponectina en el s\u00edndrome metab\u00f3lico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la diada cd40\/cd40l y su modulaci\u00f3n por la adiponectina en el s\u00edndrome metab\u00f3lico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Restituto Arangu\u00edbel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miren Nerea Varo Cenarruzabeitia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Jes\u00fas Lopez zabalza <\/li>\n<li>Fernando Bandr\u00e9s moya (vocal)<\/li>\n<li>julio Sanchez alvarez (vocal)<\/li>\n<li>Mar\u00eda victoria Cachofeiro ramos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Restituto Arangu\u00edbel En el contexto del concepto actual del s\u00edndrome metab\u00f3lico como una enfermedad inflamatoria y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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