{"id":99780,"date":"2018-03-11T10:21:00","date_gmt":"2018-03-11T10:21:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-de-necrosis-miocardica-en-insuficiencia-carda%c2%adaca-y-su-relacion-con-la-anemia\/"},"modified":"2018-03-11T10:21:00","modified_gmt":"2018-03-11T10:21:00","slug":"marcadores-de-necrosis-miocardica-en-insuficiencia-carda%c2%adaca-y-su-relacion-con-la-anemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/marcadores-de-necrosis-miocardica-en-insuficiencia-carda%c2%adaca-y-su-relacion-con-la-anemia\/","title":{"rendered":"Marcadores de necrosis mioc\u00e1rdica en insuficiencia card\u00edaca y su relaci\u00f3n con la anemia"},"content":{"rendered":"

Tesis doctoral de Mar\u00eda Esther Guisado Espartero <\/strong><\/h2>\n

Introducci\u00f3n: la anemia en la insuficiencia card\u00edaca (ic) puede causar hipoxia e incrementar la isquemia mioc\u00e1rdica, lo que elevar\u00eda los marcadores de da\u00f1o mioc\u00e1rdico y empeorar\u00eda el pron\u00f3stico. Objetivos: el objetivo principal era estudiar en los pacientes con ic la relaci\u00f3n existente entre la anemia y los marcadores s\u00e9ricos de da\u00f1o mioc\u00e1rdico (troponina t, tnt, creatinfosfoquinasa mioc\u00e1rdica, cpk-mb y prote\u00edna ligadora de \u00e1cidos grasos card\u00edacos, h-fabp) y de sobrecarga (prohormona n-terminal del p\u00e9ptido natriur\u00e9tico b, nt-probnp); as\u00ed como su valor pron\u00f3stico medido por mortalidad y eventos al a\u00f1o. Material y m\u00e9todos: se recogieron 156 pacientes consecutivos hospitalizados por ic y se les determinaron los marcadores mioc\u00e1rdicos en las primeras 72 horas del ingreso. Posteriormente se les realiz\u00f3 un seguimiento medio de 19\u00c2\u00b113 meses, recogiendo los eventos adversos (mortalidad, reingresos por ic) al a\u00f1o y al final del estudio. Resultados: el 44.2 % ten\u00edan anemia seg\u00fan los criterios de la oms. H-fabp y nt-probnp estaban significativamente aumentados en los pacientes con ic y anemia con respecto a los que no ten\u00edan anemia [mediana h-fabp (rango intercuartil): 5.06 (3.62-7.08) vs 4.06 (3.13-5.55) ng\/ml, p=0.038; mediana nt-probnp (rango intercuartil): 3203 (1087-5957) vs 1899 (970.5-4119.5) pg\/ml, p=0.043]. En el an\u00e1lisis multivariante de cox, anemia, nt-probnp elevado (\u00c2\u00bf 3818 pg\/ml) y h-fabp elevado (\u00c2\u00bf 4.988 ng\/ml) eran predictores independientes de mortalidad al a\u00f1o. Anemia y nt-probnp elevado eran tambi\u00e9n predictores independientes de evento combinado al a\u00f1o. Los pacientes que asociaban anemia y un marcador mioc\u00e1rdico elevado ten\u00edan una mayor mortalidad y eventos que los que s\u00f3lo ten\u00edan anemia (p<0.01). Conclusiones: la elevaci\u00f3n de los marcadores mioc\u00e1rdicos en los pacientes con ic y anemia puede indicar que el grado de isquemia mioc\u00e1rdica es mayor en dichos pacientes. Adem\u00e1s, los pacientes con anemia y un marcador mioc\u00e1rdico elevado (tnt, h-fabp \u00f3 nt-probnp) tienen un peor pron\u00f3stico, constituyendo grupos de mayor riesgo sobre los que habr\u00eda que intensificar el seguimiento y tratamiento.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abMarcadores de necrosis mioc\u00e1rdica en insuficiencia card\u00edaca y su relaci\u00f3n con la anemia<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores de necrosis mioc\u00e1rdica en insuficiencia card\u00edaca y su relaci\u00f3n con la anemia <\/li>\n
  • Autor:<\/strong>\u00a0 Mar\u00eda Esther Guisado Espartero <\/li>\n
  • Universidad:<\/strong>\u00a0 Sevilla<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Oscar Aramburu Bodas<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: ramon Perez cano <\/li>\n
        • francesc Formiga perez (vocal)<\/li>\n
        • Manuel Ortega calvo (vocal)<\/li>\n
        • Juan Miguel Guerrero montavez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Mar\u00eda Esther Guisado Espartero Introducci\u00f3n: la anemia en la insuficiencia card\u00edaca (ic) puede causar hipoxia e incrementar […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,139,10715],"tags":[33842,189259,122421,203499,192857,10783],"class_list":["post-99780","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-medicina-interna","category-sevilla","tag-francesc-formiga-perez","tag-juan-miguel-guerrero-montavez","tag-manuel-ortega-calvo","tag-maria-esther-guisado-espartero","tag-oscar-aramburu-bodas","tag-ramon-perez-cano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/99780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=99780"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/99780\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=99780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=99780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=99780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}