{"id":99843,"date":"2018-03-11T10:21:05","date_gmt":"2018-03-11T10:21:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aislamiento-modificacion-estructural-y-evaluacion-biologica-de-metabolitos-secundarios-de-withania-aristata-solanaceae-endemismo-canario\/"},"modified":"2018-03-11T10:21:05","modified_gmt":"2018-03-11T10:21:05","slug":"aislamiento-modificacion-estructural-y-evaluacion-biologica-de-metabolitos-secundarios-de-withania-aristata-solanaceae-endemismo-canario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/aislamiento-modificacion-estructural-y-evaluacion-biologica-de-metabolitos-secundarios-de-withania-aristata-solanaceae-endemismo-canario\/","title":{"rendered":"Aislamiento, modificacion estructural y evaluacion biologica de metabolitos secundarios de withania aristata (solanaceae), endemismo canario"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hilario Gabriel Garcia Llanos <\/strong><\/h2>\n<p>Se realiza el estudio fitoqu\u00edmico de hojas y tallos de withania aristata (solanaceae), especie end\u00e9mica de las islas canarias, la cual es usada en la medicina tradicional por sus propiedades como diur\u00e9tica, antiinflamatoria y antitumoral. Se a\u00edslan y determinan las estructuras de treinta y cinco metabolitos con esqueleto de withaesteroide, cinco fitoesteroles, seis triterpenos, un carotenoide, catorce apocarotenoides y doce alcaloides. La elucidaci\u00f3n estructural se llev\u00f3 a cabo mediante t\u00e9cnicas espectrosc\u00f3picas y espectrom\u00e9tricas, resultando veintitr\u00e9s de estos compuestos nuevos en la bibliograf\u00eda qu\u00edmica. Se prepara una quimioteca de setenta y cuatro derivados a partir de la withaferina a, metabolito mayoritario de la especie estudiada para realizar estudios de relaci\u00f3n estructura actividad (sar). Se eval\u00faa la actividad citot\u00f3xica, antimicrobiana, inmunomoduladora, antiplasm\u00f3dica y alelop\u00e1tica de los metabolitos aislados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aislamiento, modificacion estructural y evaluacion biologica de metabolitos secundarios de withania aristata (solanaceae), endemismo canario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aislamiento, modificacion estructural y evaluacion biologica de metabolitos secundarios de withania aristata (solanaceae), endemismo canario <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hilario Gabriel Garcia Llanos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel L\u00f3pez Bazzochi<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Antonio Mac\u00edas dom\u00ednguez <\/li>\n<li>Juan  ignacio Padr\u00f3n pe\u00f1a (vocal)<\/li>\n<li>Jos\u00e9 Manuel Padr\u00f3n carrillo (vocal)<\/li>\n<li>Carlos Jim\u00e9nez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hilario Gabriel Garcia Llanos Se realiza el estudio fitoqu\u00edmico de hojas y tallos de withania aristata (solanaceae), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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