{"id":99867,"date":"2018-03-11T10:21:05","date_gmt":"2018-03-11T10:21:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/molecular-mechanisms-involved-in-the-protective-effect-of-the-mediterranean-diet-and-olive-oil-consumption-in-humans\/"},"modified":"2018-03-11T10:21:05","modified_gmt":"2018-03-11T10:21:05","slug":"molecular-mechanisms-involved-in-the-protective-effect-of-the-mediterranean-diet-and-olive-oil-consumption-in-humans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-clinicas\/molecular-mechanisms-involved-in-the-protective-effect-of-the-mediterranean-diet-and-olive-oil-consumption-in-humans\/","title":{"rendered":"Molecular mechanisms involved in the protective effect of the mediterranean diet and olive oil consumption in humans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Valentini Konstantinidou <\/strong><\/h2>\n<p>El objetivo de este estudio es investigar si el papel protector de la dieta mediterr\u00e1nea tradicional (tmd) y del aceite de oliva virgen (voo), rico en compuestos fen\u00f3licos (pc), puede ser mediado a trav\u00e9s de cambios en la expresi\u00f3n g\u00e9nica. Se realizaron dos ensayos cl\u00ednicos para evaluar los efectos nutrigen\u00f3micos de la tmd y del voo, in vivo, en voluntarios sanos. Los resultados mostraron a) cambios en la expresi\u00f3n g\u00e9nica de genes relacionados con el riesgo cardiovascular tras la ingesti\u00f3n del aceite virgen de oliva, b) una infra-expresi\u00f3n en la expresi\u00f3n de genes relacionados con el proceso ateroscler\u00f3tico tras una intervenci\u00f3n con tmd de 3 meses y c) que los compuestos fen\u00f3licos del aceite de oliva ejercen un efecto nutrigen\u00f3mico protector en el marco de la tmd. Los cambios en la expresi\u00f3n g\u00e9nica fueron coherentes con los obtenidos en los marcadores de inflamaci\u00f3n sist\u00e9mica y da\u00f1o oxidativo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Molecular mechanisms involved in the protective effect of the mediterranean diet and olive oil consumption in humans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Molecular mechanisms involved in the protective effect of the mediterranean diet and olive oil consumption in humans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Valentini Konstantinidou <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Isabel Covas Planells<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antoni Trichopoulou <\/li>\n<li>dolores Corella piquer (vocal)<\/li>\n<li>Jes\u00fas De la osada Garc\u00eda (vocal)<\/li>\n<li>lydia Afman (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Valentini Konstantinidou El objetivo de este estudio es investigar si el papel protector de la dieta mediterr\u00e1nea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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