{"id":99955,"date":"2018-03-11T10:21:16","date_gmt":"2018-03-11T10:21:16","guid":{"rendered":""},"modified":"2018-03-11T10:21:16","modified_gmt":"2018-03-11T10:21:16","slug":"origen-y-efecto-de-la-palmitoilacion-de-protea%c2%adnas-caracterizacion-de-una-protea%c2%adna-palmitoil-transferasa-y-efectos-biofa%c2%adsicos-de-la-palmitoilacion-de-la-protea%c2%adna-sp-c-del-surfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/origen-y-efecto-de-la-palmitoilacion-de-protea%c2%adnas-caracterizacion-de-una-protea%c2%adna-palmitoil-transferasa-y-efectos-biofa%c2%adsicos-de-la-palmitoilacion-de-la-protea%c2%adna-sp-c-del-surfa\/","title":{"rendered":"Origen y efecto de la palmitoilaci\u00f3n de prote\u00ednas: caracterizaci\u00f3n de una prote\u00edna palmitoil-transferasa y efectos biof\u00edsicos de la palmitoilaci\u00f3n de la prote\u00edna sp-c del surfactante pulmonar."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Florian Baumgart <\/strong><\/h2>\n<p>La palmitoilaci\u00f3n de prote\u00ednas regula un gran n\u00famero de procesos celulares tanto por su funci\u00f3n en el anclaje a las membranas como por sus efectos sobre la estabilidad, funcionalidad, localizaci\u00f3n subcelular y estructura de las prote\u00ednas modificadas.  A pesar de esas m\u00faltiples funciones se desconoce en muchos casos el mecanismo molecular responsable de esos efectos. En el presente trabajo se ha estudiado la modulaci\u00f3n mediante palmitoilaci\u00f3n de la interacci\u00f3n l\u00edpido\/prote\u00edna utilizando como model o la prote\u00edna sp-c del surfactante pulmonar. Los resultados presentados en esta tesis doctoral indican que la palmitoilaci\u00f3n de esta prote\u00edna favorece su interacci\u00f3n con regiones ordenadas de membranas modelo tal y como las que existen en las membran as y pel\u00edculas interfaciales de surfactante nativo. Esta interacci\u00f3n con dominios lip\u00eddicos ordenados puede ser relevante para la funci\u00f3n de la sp-c en la estabilizaci\u00f3n de los alveolos durante la respiraci\u00f3n. Esto se demuestra en experimentos que si mulan los ciclos din\u00e1micos de compresi\u00f3n y expansi\u00f3n de la interfase aire-l\u00edquido, donde la palmitoilaci\u00f3n resulta imprescindible para estabilizar pel\u00edculas interfaciales a tensiones superficiales muy bajas y estados de alta compresi\u00f3n. En la segunda  parte de la presente tesis doctoral se ha estudiado el efecto de la palmitoilaci\u00f3n por parte de prote\u00ednas acil-transferasas celulares de la familia dhhc con especial inter\u00e9s en estudiar las consecuencias de la palmitoilaci\u00f3n a nivel celular. En part icular, se ha estudiado la isoforma dhhc19 y se ha descubierto que \u00e9sta puede sufrir una isoprenilaci\u00f3n en su segmento carboxilo-terminal. Adem\u00e1s, dhhc19 resulta ser capaz de palmitoilar espec\u00edficamente la gtpasa peque\u00f1a r-ras, aumentando su asociaci \u00f3n a regiones de la membrana resistentes a la extracci\u00f3n por detergentes, presumiblemente en estado l\u00edquido-ordenado. El incremento de la palmitoilaci\u00f3n da lugar a una mayor viabilidad de las c\u00e9lulas transfectadas con r-ras.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Origen y efecto de la palmitoilaci\u00f3n de prote\u00ednas: caracterizaci\u00f3n de una prote\u00edna palmitoil-transferasa y efectos biof\u00edsicos de la palmitoilaci\u00f3n de la prote\u00edna sp-c del surfactante pulmonar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Origen y efecto de la palmitoilaci\u00f3n de prote\u00ednas: caracterizaci\u00f3n de una prote\u00edna palmitoil-transferasa y efectos biof\u00edsicos de la palmitoilaci\u00f3n de la prote\u00edna sp-c del surfactante pulmonar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Florian Baumgart <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/03\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Perez Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>ivan Jos\u00e9 Ventoso bande (vocal)<\/li>\n<li>Manuel Prieto (vocal)<\/li>\n<li>ismael Mingarro mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Florian Baumgart La palmitoilaci\u00f3n de prote\u00ednas regula un gran n\u00famero de procesos celulares tanto por su funci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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