Tesis doctoral de Elena Figuero Ruiz
Null clinical studies have reported an increase in the prevalence and severity of gingival inflammation during pregnancy. The precise mechanism responsible for these gingival changes is unknown; however, some hypotheses have been directed towards the pote ntial role of hormones on gingival vasculature and local maternal immune system. aim: to test whether exacerbated gingival inflammation in pregnancy is associated with increased salivary hormone levels and changes in gingival crevicular fluid (gcf) interleukin-1? (Il-1?) And prostaglandin-e2 (pge2) levels. materials and methods: in this cohort study, forty-eight pregnant women without periodontitis were evaluated in the first, second and third trimesters and at three months postpartum. Twenty- eight non-periodontitis non-pregnant women were evaluated twice, with a six-month interval. Plaque and gingival indices (pli, gi), salivary progesterone and estradiol and gcf il-1? And pge2 levels were determined. Anova for repeated measures or fried man¿s test were used for intragroup analyses. Inter-group comparisons were analysed with t-test or mann whitney u-test. Correlations were evaluated with pearson¿s and spearman¿s test. results: pregnant women showed an increase in gi (pí§0.05) despite maintaining low pli values. No changes in il-1? And pge2 levels were observed during pregnancy. No significant correlation was found between the gi increase and salivary hormone levels. Gi (pí§0.05) and il-1? Levels (pí§0.001) were lower in non-pregnan t than in pregnant women. conclusions: this study confirms the presence of an exacerbated gingival inflammation during pregnancy, but this phenomenon could not be associated with an increase in progesterone or estradiol or with changes in pge2 or il- 1?. The elevated il-1? Levels observed may result from the creation of a favourable local environment rather than from direct effects of sex hormones. in a second phase, an experimental in vitro study was done to test the effects of some phytohormon es called phytoestrogens. The use of agents with estrogenic activity (phytoestrogens), but without their negative side-effects would be a great advance in the treatment of periodontal diseases. aim: to investigate potential oxidant / antioxidant inte ractions of nicotine with phytoestrogens and antioxidants (co-enzyme q10 (coq), pycnogenol) in a cell culture model. material and methods: duplicate incubations of human periosteal fibroblasts and osteoblasts were performed with 14c-testosterone as
Datos académicos de la tesis doctoral «Influencia de las variaciones hormonales en el periodonto.«
- Título de la tesis: Influencia de las variaciones hormonales en el periodonto.
- Autor: Elena Figuero Ruiz
- Universidad: Complutense de Madrid
- Fecha de lectura de la tesis: 17/09/2009
Dirección y tribunal
- Director de la tesis
- Rocio Cerero Lapiedra
- Tribunal
- Presidente del tribunal: ricardo Manuel Casaleiro lobo de faria almeida
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